University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
Saarland University Hospital, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. K. Freier), Kirrberger Straße, D-66424 Homburg, Germany.
J Craniomaxillofac Surg. 2020 Dec;48(12):1158-1163. doi: 10.1016/j.jcms.2020.10.006. Epub 2020 Nov 1.
Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning.
A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection.
120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies.
Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients.
口腔鳞状细胞癌根据其局部位置表现出不同的疾病进展模式。本研究旨在评估下颌牙槽突肿瘤患者的临床病理数据，以方便风险评估和治疗计划。
设计了一项回顾性队列研究，纳入了下颌牙龈鳞状细胞癌患者。收集了临床和病理数据，以确定根据肿瘤分期、定位（前、中、后）和肿瘤切除范围，颈部转移和临床结果的发生率。
共纳入 120 例患者。转移率为 42.6%。下颌前份的肿瘤显示出更高的双侧转移率（前份：85.7%，中份：15.8%，后份：4%，p<0.001）和局部复发率（前份：25%，中份：16.3%，后份：5.5%，p=0.03），与后份恶性肿瘤相比。
下颌前份的肿瘤具有较高的转移率和局部复发率。因此，我们建议对这些患者进行根治性节段切除术和双侧颈部淋巴结清扫术。
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