Li Shixing, Lou Xuelei, Chang Zukuan, Shi Chaoheng, Lu Huilin, Han Jiankui
Department of Interventional Therapy, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
Exp Ther Med. 2020 Dec;20(6):274. doi: 10.3892/etm.2020.9404. Epub 2020 Oct 27.
The present study aimed to investigate the efficacy of neurointervention combined with intravenous thrombolysis in the treatment of ischemic cerebrovascular disease (ICD) and its influence on the neurological function and prognosis of patients. A total of 119 patients with ICD admitted to Xinxiang Central Hospital (Xinxiang, China) from May 2013 to September 2015 were selected. Among them, 65 patients were enrolled in the control group and treated with intravenous thrombolysis, whereas the other 54 patients were enrolled in the observation group and were treated with intravenous thrombolysis combined with neurointervention. The National Institute of Health Stroke Scale (NIHSS) system was used to evaluate the neurological function of patients after treatment. Kaplan-Meier survival curve analysis was carried out to assess the survival of patients. The total effective rate, complications, vascular recanalization and the hospitalization time after treatment were compared between the two groups. The NIHSS scores at 1, 3 and 6 months after treatment were statistically lower in the observation group than those in the control group (P<0.05). The total effective rate and total vascular recanalization in the observation group were higher than those of the control group (P<0.05). The incidence of complications in the observation group was statistically lower than that in the control group (P<0.05). In conclusion, neurointervention combined with intravenous thrombolysis can not only effectively improve the diseased blood vessels of patients and restore the damaged nerve function, but also reduce the incidence of complications. Moreover, neurointervention combined with intravenous thrombolysis is safe and can ensure a better quality of life of patients.
本研究旨在探讨神经介入联合静脉溶栓治疗缺血性脑血管病（ICD）的疗效及其对患者神经功能和预后的影响。选取2013年5月至2015年9月在新乡市中心医院（中国新乡）收治的119例ICD患者。其中，65例患者纳入对照组，接受静脉溶栓治疗；另外54例患者纳入观察组，接受静脉溶栓联合神经介入治疗。采用美国国立卫生研究院卒中量表（NIHSS）系统评估患者治疗后的神经功能。进行Kaplan-Meier生存曲线分析以评估患者的生存情况。比较两组治疗后的总有效率、并发症、血管再通情况及住院时间。观察组治疗后1、3和6个月时的NIHSS评分均低于对照组（P<0.05）。观察组的总有效率和总血管再通率高于对照组（P<0.05）。观察组并发症的发生率低于对照组（P<0.05）。综上所述，神经介入联合静脉溶栓不仅能有效改善患者病变血管，恢复受损神经功能，还能降低并发症的发生率。此外，神经介入联合静脉溶栓安全可靠，可确保患者有更好的生活质量。
