母亲接受减肥手术后出生儿童的肥胖、精神运动和行为结局。

Adiposity, psychomotor and behaviour outcomes of children born after maternal bariatric surgery.

作者信息

Van De Maele Karolien, Bogaerts Annick, De Schepper Jean, Provyn Steven, Ceulemans Dries, Guelinckx Isabelle, Gies Inge, Devlieger Roland

机构信息

Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Research Unit Organ Systems, Department of Development and Regeneration, Catholic University of Leuven, Leuven, Belgium.

出版信息

Pediatr Obes. 2021 May;16(5):e12749. doi: 10.1111/ijpo.12749. Epub 2020 Nov 17.

DOI:10.1111/ijpo.12749

PMID:33200544

Abstract

BACKGROUND

Bariatric surgery before pregnancy can result in improved maternal fertility. However, long-term data on the consequences at childhood age are currently lacking.

METHODS

EFFECTOR is a prospective cohort study of children (aged 4 to 11 years) born to mothers who underwent bariatric surgery (BS) before pregnancy (n = 36), controls with overweight/obesity (OW/OB) matched on pre-pregnancy BMI (n = 36) and normal weight controls (NL) (n = 35). We performed prospective collection of anthropometric data, data on psychomotor development, school functioning and behaviour (Strengths and Difficulties Questionnaire (SDQ), Child Behaviour Checklist (CBCL)).

RESULTS

The children born after bariatric surgery (BS) presented with the highest body-weight SDS (0.70 vs 0.14 in OW/OB and -0.09 in NL; P = .006) and BMI SDS (0.47 vs -0.02 in OW/OB and -0.42 in NL; P = .01). A higher excess in body fat percentage and waist circumference SDS were found in the BS group (5.7 vs 1.4 in OW/OB and -0.1 in NL; P < .001 and 0.61 vs 0.16 in OW/OB and -0.15 in NL; P = .04). The SDQ questionnaires revealed a higher amount of overall problems in the BS offspring (11.1 vs 7.5 in OW/OB and 8.1 in NL; P = .03), with a higher externalizing score at the CBCL (52.0 vs 44.2 in OW/OB and 47.0 in NL; P = .03).

CONCLUSION

Maternal bariatric surgery does not appear to protect the offspring for childhood overweight and obesity. Parents reported more behaviour problems in these children, especially externally of nature.

摘要

背景

孕期前进行减肥手术可提高产妇生育能力。然而，目前缺乏关于儿童期后果的长期数据。

方法

EFFECTOR是一项前瞻性队列研究，研究对象为母亲在孕期前接受减肥手术（BS）的儿童（4至11岁）（n = 36）、孕前BMI匹配的超重/肥胖（OW/OB）对照儿童（n = 36）和正常体重对照儿童（NL）（n = 35）。我们前瞻性收集了人体测量数据、心理运动发育数据、学校功能和行为数据（优势与困难问卷（SDQ）、儿童行为检查表（CBCL））。

结果

减肥手术后出生的儿童体重标准差评分最高（OW/OB组为0.14，NL组为 -0.09，BS组为0.70；P = 0.006），BMI标准差评分也最高（OW/OB组为 -0.02，NL组为 -0.42，BS组为0.47；P = 0.01）。BS组的体脂百分比和腰围标准差评分更高（OW/OB组为1.4，NL组为 -0.1，BS组为5.7；P < 0.001；OW/OB组为0.16，NL组为 -0.15，BS组为0.61；P = 0.04）。SDQ问卷显示，BS组后代的总体问题更多（OW/OB组为7.5，NL组为8.1，BS组为11.1；P = 0.03），CBCL的外化得分更高（OW/OB组为44.2，NL组为47.0，BS组为52.0；P = 0.03）。