Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
College of Pharmacy, Almaarefa University, Riyadh, Saudi Arabia.
Drug Deliv. 2020 Nov 9;27(1):1625-1643. doi: 10.1080/10717544.2020.1846638.
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a significant role in the biological behavior of the SDs. SDs have been prepared using a variety of pharmaceutically acceptable polymers utilizing various novel technologies. In the recent years, much attention has been paid toward the use of novel carriers and methodologies in exploring novel types of SDs to enhance therapeutic efficacy and bioavailability. The use of novel carriers and methodologies would be very beneficial for formulation scientists to develop some SDs-based formulations for their commercial use and clinical applications. In the present review, current literature of novel methodologies for SD preparation to enhance the dissolution rate, solubility, therapeutic efficacy, and bioavailability of poorly water-soluble drugs has been summarized and analyzed. Further, the current status of SDs, patent status, and future prospects have also been discussed.
在过去的几十年中，固体分散体（SD）技术已被研究用于制备无定形载体，以提高水溶性差的药物的溶解度、溶出速率和生物利用度。在 SD 的制备中，合适的载体和方法在 SD 的生物学行为中起着重要作用。已经使用各种药用可接受的聚合物并利用各种新颖技术来制备 SD。近年来，人们非常关注在探索新型 SD 时使用新型载体和方法来提高治疗效果和生物利用度。对于制剂科学家来说，使用新型载体和方法将非常有利于开发一些基于 SD 的制剂以用于商业用途和临床应用。在本综述中，总结和分析了目前用于提高水溶性差的药物的溶解速率、溶解度、治疗效果和生物利用度的 SD 制备的新颖方法的文献。此外，还讨论了 SD 的现状、专利状况和未来前景。
