Fong Hee Kong, Gandhi Zainab J, Malik Faizan A, Panchal Ankur, Savani Sejal, Doshi Rajkumar, Desai Rupak
Cardiovascular Medicine, University of California Davis Medical Center, Sacramento, USA.
Internal Medicine, C.U. Shah Medical College, Surendranagar, IND.
Cureus. 2020 Oct 16;12(10):e10985. doi: 10.7759/cureus.10985.
Background There is very scarce data about the shifting landscape of complications like venous thromboembolic events (VTE) and respiratory failure in Takotsubo syndrome (TTS). We have assessed the rates and trends of these complications in (TTS)-related hospitalizations. Methods The National Inpatient Sample (2007-2014) was queried to identify adult hospitalizations for TTS and subsequent VTE and respiratory failure using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9 CM) codes. Trends were assessed using discharge weights and the linear-by-linear association test for the overall cohort and subgroups based on age, sex, and race. Results Of 156,506 admissions for TTS from 2007-2014, 3.5% (N=5,550) of admissions revealed VTE whereas 17.4% (N=27,252) of admissions revealed respiratory failure. There were significantly rising trends in VTE (from 2.2% to 4.2%) and respiratory failure (10% to 20.7%) with TTS (p<0.05) from 2007-2014. On subgroup analysis, all subgroups showed rising trends in VTE and respiratory failure. However, young (18-44 years), male patients admitted with TTS demonstrated a greater surge in VTE as compared to other groups. In contrast, the frequency of respiratory failure rose more significantly in young, male, non-white TTS patients compared to older, female and white TTS patients. Conclusion There were alarming trends in the VTE and respiratory failure despite the improved understanding of TTS etiopathogenesis and advanced diagnostic modalities among TTS-related admissions, mostly comprising of young, male, and non-white patients. Introduction.
关于诸如静脉血栓栓塞事件（VTE）和应激性心肌病（TTS）中的呼吸衰竭等并发症不断变化的情况，现有数据非常稀少。我们评估了这些并发症在与TTS相关的住院治疗中的发生率和趋势。方法：查询国家住院样本（2007 - 2014年），使用国际疾病分类第九版临床修订本（ICD - 9 CM）编码来识别因TTS住院的成年患者以及随后发生的VTE和呼吸衰竭情况。基于年龄、性别和种族，使用出院权重和线性 - 线性关联检验评估总体队列和亚组的趋势。结果：在2007 - 2014年的156,506例TTS入院病例中，3.5%（N = 5,550）的入院病例出现VTE，而呼吸衰竭的发生率为17.4%（N = 27,252）。在2007 - 2014年期间，TTS患者中VTE（从2.2%升至4.2%）和呼吸衰竭（从10%升至20.7%）的发生率呈显著上升趋势（p < 0.05）。亚组分析显示，所有亚组的VTE和呼吸衰竭发生率均呈上升趋势。然而，与其他组相比，患有TTS的年轻（18 - 44岁）男性患者的VTE发生率上升幅度更大。相比之下，年轻、男性、非白人的TTS患者呼吸衰竭的发生率比老年、女性和白人TTS患者上升更为显著。结论：尽管对TTS的病因发病机制有了更好的理解，并且在TTS相关的住院治疗中采用了先进的诊断方法，但VTE和呼吸衰竭的发生率仍呈惊人的上升趋势，这些住院患者大多为年轻、男性和非白人患者。引言。
