Louis R, Calmes D, Frix A N, Schleich F
Service d'Allergologie-Pneumologie, CHU Liège, Belgique.
Rev Med Liege. 2020;75(S1):130-132.
Given the prominent role of respiratory viruses in asthma exacerbations it has been feared that the SARS-CoV-2 pandemic may result in massive irruption of asthmatic patients in the hospital emergency departments. It seems, however, that asthma is not a particular risk factor for SARS-COV-2 infection nor for death resulting from severe infection. Inhaled corticosteroids (ICS) were found to reduce expression of ACE2 receptor in sputum cells, thereby maybe reducing the risk of lung infection. Only the more severe asthmatic patients treated with oral corticoids or high dose ICS were found to be at risk of death, presumably because of associated comorbidities. Biologicals directed towards IgE or interleukin-5 do not seem to confer an increased risk of severe infection.
鉴于呼吸道病毒在哮喘急性加重中起着重要作用,人们担心新冠疫情可能导致大量哮喘患者涌入医院急诊科。然而,哮喘似乎并非新冠病毒感染的特殊风险因素,也不是严重感染导致死亡的特殊风险因素。吸入性糖皮质激素(ICS)可降低痰细胞中ACE2受体的表达,从而可能降低肺部感染风险。仅发现接受口服皮质类固醇或高剂量ICS治疗的重度哮喘患者有死亡风险,可能是由于相关合并症。针对IgE或白细胞介素-5的生物制剂似乎不会增加严重感染风险。