Biomedical Science Department, Institute of Ophthalmology, University of Messina, Via Consolare Valeria, 1, Messina, Italy.
Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi" Division of Microbiology, University of Messina, Messina, Italy.
Sci Rep. 2020 Nov 19;10(1):20178. doi: 10.1038/s41598-020-77194-9.
To evaluate the ocular manifestation in patients hospitalized with coronavirus disease 2019 (COVID-19) and to search for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tears. This study was conducted in 29 hospitalized patients who were admitted to the COVID center at the Policlinic Hospital of the University of Messina, Italy. All patients underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire, anterior segment, and the ocular surface examination of both eyes using a portable slit lamp. The Schirmer I test was performed, and the filter paper strip was used to search for the presence of SARS-CoV-2 on the ocular surface by real-time quantitative polymerase chain reaction (RT-qPCR). A total of 10 patients reported ocular symptoms; in particular, four reported eye burning, three reported foreign body sensation, and three reported tearing. Moreover, seven patients presented conjunctival hyperemia and/or chemosis, eleven patients presented blepharitis signs such as lid margin hyperemia and/or telangiectasia, crusted eyelashes, and meibomian orifices alterations. Tear analysis did not reveal the presence of SARS-CoV-2. Ocular symptoms are common in patients with COVID-19; although, tear analysis did not reveal the presence of SARS-CoV-2.
评估因 2019 年冠状病毒病（COVID-19）住院的患者的眼部表现，并寻找严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）在泪液中的存在。这项研究在意大利墨西拿大学综合医院 COVID 中心住院的 29 名患者中进行。所有患者均接受眼科评估，包括干眼症标准化患者评估（SPEED）问卷、眼前节和便携式裂隙灯对双眼的眼表检查。进行 Schirmer I 测试，并使用滤纸条通过实时定量聚合酶链反应（RT-qPCR）在眼表面上搜索 SARS-CoV-2 的存在。共有 10 名患者报告了眼部症状；具体来说，4 名患者报告眼睛灼热，3 名患者报告异物感，3 名患者报告流泪。此外，7 名患者出现结膜充血和/或水肿，11 名患者出现睑缘充血和/或毛细血管扩张、结痂睫毛和睑板腺或泪小点改变等睑炎迹象。泪液分析未发现 SARS-CoV-2 的存在。眼部症状在 COVID-19 患者中很常见；尽管如此，泪液分析并未发现 SARS-CoV-2 的存在。
