Department of Medicine, Medical Microbiology, University of Perugia, Perugia, Italy.
Microbiology, Perugia General Hospital, Perugia, Italy.
Future Microbiol. 2020 Oct;15:1595-1605. doi: 10.2217/fmb-2020-0177. Epub 2020 Nov 20.
Accelerate Pheno™ (ACC) is a fully automated system providing rapid identification of a panel of bacteria and yeasts, and antimicrobial susceptibility testing of common bacterial pathogens responsible for bloodstream infections and sepsis. Diagnostic accuracy for identification ranges from 87.9 to 100%, and antimicrobial susceptibility testing categorical agreement is higher than 91%. The present review includes peer-reviewed studies on ACC published to date. Both interventional and hypothetical studies evidenced the potential positive clinical role of ACC in the management and therapy of patients with bloodstream infections and sepsis, due to the important reduction in time to report, suggesting a crucial impact on the therapeutic management of these patients, provided the presence of a hospital antimicrobial stewardship program, a 24/7 laboratory operating time and a strict collaboration between clinical microbiologist and clinician. Further prospective multicenter studies are necessary to explore the impact of this system on mortality, length of stay and spread of multidrug-resistant organisms.
Accelerate Pheno™（ACC）是一个全自动系统，可快速鉴定一组细菌和酵母菌，并对引起血流感染和败血症的常见细菌病原体进行抗菌药物敏感性测试。鉴定的诊断准确性为 87.9%至 100%，抗菌药物敏感性测试的分类一致性高于 91%。本综述包括迄今为止发表的关于 ACC 的同行评审研究。干预性和假设性研究都证明了 ACC 在管理和治疗血流感染和败血症患者方面具有潜在的积极临床作用，因为报告时间的重要缩短，这对这些患者的治疗管理产生了至关重要的影响，前提是医院有抗菌药物管理计划、24/7 实验室运行时间以及临床微生物学家和临床医生之间的严格合作。需要进一步进行前瞻性多中心研究，以探讨该系统对死亡率、住院时间和多药耐药菌传播的影响。
