爱尔兰曾对有过非肾脏实体器官移植史的肾移植受者进行过肾移植，本文回顾性研究了其短期和长期结果。

The Irish experience of kidney transplantation among recipients with prior non-renal solid organ transplants: A retrospective study on short- and long-term outcomes.

机构信息

National Kidney Transplant Service (NKTS), Department of Transplant, Urology, Nephrology (TUN), Beaumont Hospital, Dublin, Ireland.

National Kidney Transplant Service (NKTS), Department of Data and Biostatistics, Beaumont Hospital, Dublin, Ireland.

出版信息

Clin Transplant. 2021 Jan;35(1):e14156. doi: 10.1111/ctr.14156. Epub 2020 Dec 12.

DOI:10.1111/ctr.14156

PMID:33222237

Abstract

BACKGROUND

This study aims to evaluate allograft and patient outcomes among recipients of kidney transplants after non-renal solid organ transplants. We also aim to compare our findings with recipients of a repeat kidney transplant.

METHODS

We performed an analysis on kidney transplant recipients who underwent kidney transplantation after a non-renal solid organ transplant. Survival data were stratified into 2 groups: Group A (n = 37) consisted of recipients of a kidney transplant after prior non-renal solid organ transplant, and Group B (n = 330) consisted of recipients of a repeat kidney transplant.

RESULTS

The 1-,5-, and 10-year graft survival (death-censored) for recipients of a kidney transplant post-non-renal solid organ transplant (Group A) were 97.3%, 91.5%, and 86.9%, compared with 97.9%, 90.2%, and 83.4% for recipients of a repeat kidney transplant (Group B) (p = .32). The 1-, 5-, and 10-year patient survival rates were 97.3%, 82.7%, and 79.1% in Group A compared to 97.9%, 90.2%, and 83.4% in Group B. Unadjusted overall patient survival was significantly lower for Group A (p = .017).

CONCLUSION

Kidney transplant recipients who have undergone a previous non-renal solid organ transplant have similar allograft survival outcomes, but higher long-term mortality rates compared to repeat kidney transplant recipients.

摘要

背景

本研究旨在评估接受过非肾脏实体器官移植的肾移植受者的移植物和患者结局。我们还旨在将我们的发现与重复肾移植受者进行比较。

方法

我们对接受过非肾脏实体器官移植的肾移植受者进行了分析。生存数据分为两组：A 组（n=37）由先前接受过非肾脏实体器官移植的肾移植受者组成，B 组（n=330）由重复肾移植受者组成。

结果

接受过非肾脏实体器官移植后的肾移植受者的 1 年、5 年和 10 年移植物存活率（死亡删失）分别为 97.3%、91.5%和 86.9%，而重复肾移植受者的 1 年、5 年和 10 年移植物存活率分别为 97.9%、90.2%和 83.4%（p=0.32）。A 组的 1 年、5 年和 10 年患者生存率分别为 97.3%、82.7%和 79.1%，而 B 组的 1 年、5 年和 10 年患者生存率分别为 97.9%、90.2%和 83.4%。未调整的总体患者生存率在 A 组显著较低（p=0.017）。