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动脉导管未闭的干预措施及其对先天性心脏病的影响。

Interventions on patent ductus arteriosus and its impact on congenital heart disease.

作者信息

Zaidi Mariam, Sorathia Nilofer, Abbasi Hannah, Khashkhusha Arwa, Harky Amer

机构信息

Charing Cross Hospital, Imperial College London, London, UK.

St George's University of London, London, UK.

出版信息

Cardiol Young. 2020 Nov;30(11):1566-1571. doi: 10.1017/S1047951120004126. Epub 2020 Nov 23.

Abstract

The ductus arteriosus (DA) connects the pulmonary artery to the aorta to bypass the pulmonary circulation in utero. It normally closes within 24-72 hours after birth due to increased pulmonary resistance from an increase in oxygen partial pressure with the baby's first breath. Medical treatment can help close the DA in certain situations where closure is delayed. However, in duct-dependent cardiac defects, the presence of the DA is crucial for survival and as such medical and surgical techniques have evolved to prevent closure. This review aims to outline the two main management options for keeping a ductus arteriosus patent. This includes stenting the PDA and shunting via a modified Blalock-Taussig shunt. Whilst both techniques exist, multicentre trials have found equal mortality end points but significantly reduced morbidity with stenting than shunting. This is also reflected by shorter recovery times, reduced requirement for extracorporeal membrane oxygenation (ECMO), and improved quality of life, although stent longevity remains a limiting factor.

摘要

动脉导管(DA)连接肺动脉和主动脉,在子宫内绕过肺循环。由于婴儿第一次呼吸时氧分压升高导致肺阻力增加,它通常在出生后24 - 72小时内关闭。在某些关闭延迟的情况下,药物治疗有助于关闭动脉导管。然而,在依赖动脉导管的心脏缺陷中,动脉导管的存在对生存至关重要,因此医学和外科技术已经发展以防止其关闭。本综述旨在概述保持动脉导管开放的两种主要管理选择。这包括对动脉导管未闭进行支架置入和通过改良的布莱洛克 - 陶西格分流术进行分流。虽然这两种技术都存在,但多中心试验发现死亡率终点相同,但支架置入术的发病率明显低于分流术。这也体现在恢复时间更短、体外膜肺氧合(ECMO)需求减少以及生活质量提高上,尽管支架寿命仍然是一个限制因素。

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