Interventional Cardiology, Department of Cardiology, Advocate Illinois Masonic Medical Center, 3134 North Clark Street, Chicago, IL 60657, USA.
Stroke Section, Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 South Wood Street, Chicago, IL 60612, USA.
Neurol Clin. 2021 Feb;39(1):51-69. doi: 10.1016/j.ncl.2020.09.013. Epub 2020 Nov 7.
Up to a third of strokes are cryptogenic. The prevalence of patent foramen ovale (PFO) in patients with cryptogenic stroke is higher than in individuals with stroke of known origin. It has been proposed that some cryptogenic strokes can be caused by paradoxic embolism across a PFO. The treatment of PFO includes medical treatment with antithrombotic agents and percutaneous PFO closure. There is limited evidence to support PFO closure in unselected cases of cryptogenic stroke. However, large randomized clinical trials confirmed the superiority of transcatheter PFO closure compared with medical treatment in young patients with cryptogenic stroke.
高达三分之一的中风是隐源性的。患有隐源性中风的患者中，卵圆孔未闭 (PFO) 的患病率高于患有已知病因的中风患者。有人提出，一些隐源性中风可能是由于 PFO 内的反常栓塞引起的。PFO 的治疗包括使用抗血栓药物的药物治疗和经皮 PFO 封堵术。目前仅有有限的证据支持在隐源性中风的非选择性病例中进行 PFO 封堵。然而，大型随机临床试验证实了在年轻的隐源性中风患者中，经导管 PFO 封堵术优于药物治疗。
