新型冠状病毒肺炎出院患者SARS-CoV-2 RNA复阳的临床特征及结局
Clinical characteristics and outcomes of discharged COVID-19 patients with reoccurrence of SARS-CoV-2 RNA.
作者信息
Wu Jing, Xia Xiao-Ying, Liu He-Lei, Xia Hong, Huang Wen-Xiang, Jia Bei, Peng Feng-Ying
机构信息
Department of Infectious Disease, The People's Hospital of Dazu District, Chongqing 402360, China.
Key Laboratory of Infectious & Parasitic Diseases in Chongqing, Department of Infectious Disease, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
出版信息
Future Virol. 2020 Oct;15(10):663-671. doi: 10.2217/fvl-2020-0142.
AIM
Data are limited on clinical characteristics and outcomes of recovered the 2019 coronavirus disease (COVID-19) patients with the reoccurrence of SARS-CoV-2 RNA.
PATIENTS & METHODS: Discharged patients in our hospital were included, who had recovered from COVID-19 with the reoccurrence of SARS-CoV-2 RNA.
RESULTS
Six patients were redetectable and positive for SARS-CoV-2 RNA after discharge from 3 to 15 days. The main symptoms, although no fever, included fatigue, dry cough and pharyngeal or chest discomfort, which were generally milder in the repositive period compared with the period of initial infection. Their laboratory indexes were significantly improved compared with the initial infection, and the pulmonary lesions were continuously improving. All close contacts were SARS-CoV-2 RNA-negative.
CONCLUSION
No worsening outcomes or active transmission to close contacts were found for the repositive COVID-19 patients.
目的
关于2019冠状病毒病（COVID-19）康复患者出现严重急性呼吸综合征冠状病毒2（SARS-CoV-2）RNA复发的临床特征和结局的数据有限。
患者与方法
纳入我院出院的COVID-19康复且出现SARS-CoV-2 RNA复发的患者。
结果
6例患者在出院后3至15天可重新检测到SARS-CoV-2 RNA呈阳性。主要症状虽无发热，但包括乏力、干咳及咽部或胸部不适，与初次感染期相比，再次阳性期症状通常较轻。与初次感染相比，其实验室指标显著改善，肺部病变持续好转。所有密切接触者SARS-CoV-2 RNA均为阴性。
结论
COVID-19再次阳性患者未出现病情恶化或向密切接触者的主动传播。
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