Kitahara Satoshi, Kataoka Yu, Sugane Hiroki, Otsuka Fumiyuki, Asaumi Yasuhide, Noguchi Teruo, Yasuda Satoshi
Department of Cardiovascular Medicine, National Cerebral & Cardiovascular Center, Suita, Osaka, Japan.
Department of Cardiovascular Medicine, Chikamori Hospital, Kochi, Japan.
Cardiovasc Diagn Ther. 2020 Oct;10(5):1461-1479. doi: 10.21037/cdt-20-238.
imaging of plaque instability has been considered to have a great potential to predict future coronary events and evaluate the stabilization effect of novel anti-atherosclerotic medical therapies. Currently, there are several intravascular imaging modalities which enable to visualize plaque components associated with its vulnerability. These include virtual histology intravascular ultrasound (VH-IVUS), integrated backscatter IVUS (IB-IVUS), optical coherence tomography (OCT), near-infrared spectroscopy and coronary angioscopy. Recent studies have shown that these tools are applicable for risk stratification of cardiovascular events as well as drug efficacy assessment. However, several limitation exists in each modality. The current review paper will outline advantages and limitation of VH-IVUS, IB-IVUS, OCT, NIRS and coronary angioscopy imaging.
斑块不稳定性成像被认为在预测未来冠状动脉事件以及评估新型抗动脉粥样硬化药物治疗的稳定效果方面具有巨大潜力。目前，有几种血管内成像方式能够使与斑块易损性相关的斑块成分可视化。这些方式包括虚拟组织学血管内超声（VH-IVUS）、背向散射积分血管内超声（IB-IVUS）、光学相干断层扫描（OCT）、近红外光谱以及冠状动脉血管镜检查。最近的研究表明，这些工具适用于心血管事件的风险分层以及药物疗效评估。然而，每种方式都存在一些局限性。本综述文章将概述VH-IVUS、IB-IVUS、OCT、近红外光谱（NIRS）和冠状动脉血管镜检查成像的优点和局限性。
