National Center for Phthisiology, Bishkek, Kyrgyz Republic.
TB Research and Prevention Centre, Yerevan, Armenia.
J Infect Dev Ctries. 2020 Nov 16;14(11.1):101S-108S. doi: 10.3855/jidc.11897.
Tuberculosis (TB) is a global public health problem. The incidence of TB is especially high among TB key populations, such as the homeless, people who use drugs, prisoners, and migrants. The study aimed to assess the associations between affiliation to TB key populations and treatment outcome.
This retrospective cross-sectional study used data extracted from the National TB Registry of Kyrgyzstan for the region of Chuy (including the city of Bishkek) for 2015-2017. Descriptive statistics was used to summarize the data. Logistic regression was used to assess the associations.
The study included 1,526 patients among whom more than half (52.5%) fell into the youngest group (18-35 years old). Migrants were the most highly represented group comprising 67.8% of all TB key populations. Men (63.0%) and patients with pulmonary TB (83.0%) prevailed in the cohort. The proportions of patients who had completed the treatment were high among all the key populations. Logistic regression was used to assess the association between affiliation to a certain TB key population and the TB treatment outcome. Patients who belonged to more than one TB key population were found to have the highest risk of unsuccessful TB treatment outcomes, both in the region of Chuy (OR = 9.9, 95% CI 2.0-48.1, p = 0.04) and the city of Bishkek (OR = 24.9, 95% CI 7.2-86.4, p < 0.001).
The homeless, people who use drugs, ex-prisoners, and TB patients who belonged to more than one TB key population were found to have higher risks of unsuccessful TB treatment outcome in comparison to migrants.
结核病（TB）是一个全球性的公共卫生问题。结核病的发病率在结核病重点人群中尤其高，如无家可归者、吸毒者、囚犯和移民。本研究旨在评估与结核病重点人群有关的关联和治疗结果。
本回顾性横断面研究使用了 2015-2017 年从吉尔吉斯斯坦国家结核病登记处提取的来自吉尔吉斯斯坦楚伊地区（包括比什凯克市）的数据。使用描述性统计来总结数据。使用逻辑回归来评估关联。
该研究纳入了 1526 名患者，其中超过一半（52.5%）属于最年轻的年龄组（18-35 岁）。移民是占比最高的群体，占所有结核病重点人群的 67.8%。男性（63.0%）和肺结核患者（83.0%）在队列中占主导地位。所有重点人群中完成治疗的患者比例都很高。使用逻辑回归来评估与特定结核病重点人群的关联与结核病治疗结果之间的关系。属于多个结核病重点人群的患者被发现结核病治疗结果失败的风险最高，无论是在楚伊地区（OR=9.9，95%CI 2.0-48.1，p=0.04）还是比什凯克市（OR=24.9，95%CI 7.2-86.4，p<0.001）。
与移民相比，无家可归者、吸毒者、前囚犯和属于多个结核病重点人群的结核病患者被发现结核病治疗结果失败的风险更高。
