儿童质子泵抑制剂超敏反应。

Hypersensitivity reactions to proton pump inhibitors in childhood.

机构信息

Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

UOC Pediatria, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", Ancona, Italy.

出版信息

Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26:29-32. doi: 10.1111/pai.13345.

DOI:10.1111/pai.13345

PMID:33236429

Abstract

Hypersensitivity reactions (HRs) to proton pump inhibitors (PPIs) are mainly described in adults. Anyway, increased use of PPIs in childhood has been observed in recent years. In the literature, only case reports are published on children. Most of the PPI HRs are IgE-mediated. Skin test concentrations and allergy workup protocols used for adults are also applied in children. This study underlies that multicentric pediatric studies focusing on PPI reactions in children are needed.

摘要

质子泵抑制剂（PPIs）过敏反应（HRs）主要在成人中描述。然而，近年来观察到儿童中 PPI 的使用增加。文献中仅发表了关于儿童的病例报告。大多数 PPI HRs 是 IgE 介导的。在儿童中也应用了成人中使用的皮肤试验浓度和过敏工作流程方案。本研究表明，需要进行针对儿童 PPI 反应的多中心儿科研究。