School of Environmental Science and Engineering, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Nanjing University of Information Science and Technology, Nanjing, 210044, People's Republic of China.
State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, People's Republic of China.
Bull Environ Contam Toxicol. 2020 Dec;105(6):841-846. doi: 10.1007/s00128-020-03052-z. Epub 2020 Nov 25.
We experimentally investigated the toxicity of stannic oxide nanoparticles (SnO NPs) to three freshwater species including Scenedesmus obliquus, Daphnia magna, and Danio rerio. To evaluate effect, toxicological impacts were compared to that of stannic chloride (SnCl). Based on the actual concentration of Sn, SnO NPs suspensions inhibited growth of S. obliquus in a dose-dependent manner, demonstrating a median effect concentration of 2.28 ± 0.53 mg/L. However, SnO NP suspensions were found to exhibit limited acute toxicity in D. magna and D. rerio. Moreover, the toxicity of the SnO NP suspension was lower than SnCl for all three trophic aquatic organisms. Comparison of component-specific contribution to overall toxicity indicated that, in SnO NP suspensions, particulate Sn more significantly contributed to toxicity than dissolved Sn-ions. Furthermore, we found that the toxic mechanism of the SnO NP suspension involved the induction of oxidative stress by increasing intracellular ROS accumulation.
我们通过实验研究了氧化锡纳米粒子（SnO NPs）对三种淡水物种的毒性，包括斜生栅藻、大型溞和斑马鱼。为了评估其效应，我们将其毒性影响与氯化锡（SnCl）进行了比较。基于 Sn 的实际浓度，SnO NPs 悬浮液以剂量依赖的方式抑制了斜生栅藻的生长，表现出 2.28 ± 0.53 mg/L 的中值效应浓度。然而，我们发现 SnO NP 悬浮液对大型溞和斑马鱼表现出有限的急性毒性。此外，对于所有三种营养型水生生物，SnO NP 悬浮液的毒性均低于 SnCl。对整体毒性的成分特异性贡献的比较表明，在 SnO NP 悬浮液中，颗粒态 Sn 比溶解态 Sn-离子对毒性的贡献更大。此外，我们发现 SnO NP 悬浮液的毒性机制涉及通过增加细胞内 ROS 积累来诱导氧化应激。
