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[药物基因组学:改善药物处方的工具箱]

[Pharmacogenomics : a toolbox to improve drug prescription].

作者信息

Jaccard Evrim, Redin Claire, Girardin François, Waeber Gérard, Fellay Jacques, Vollenweider Peter

机构信息

Service de médecine interne, Département de médecine, CHUV, 1011 Lausanne.

Unité de médecine de précision, Département des laboratoires, CHUV, 1010 Lausanne.

出版信息

Rev Med Suisse. 2020 Nov 25;16(716):2259-2263.

Abstract

As a result of advances in pharmacogenomics (PGx), the paradigm that a single dose of a drug is extrapolated to an entire population is set to change. Personalising drug prescriptions according to individual genomic determinants would make it possible to increase the effectiveness and tolerance of treatments. In Switzerland, any doctor can prescribe validated PGx tests for five actionable drugs : abacavir, carbamazepine, thiopurines [azathioprine], fluoropyrimidines [5-FU, capecitabine] and irinotecan. Such an approach presupposes that PGx data are shared with trained clinicians and that prescribing aids can guide them.

摘要

由于药物基因组学(PGx)的进展,将单一药物剂量外推至整个人口的模式即将改变。根据个体基因组决定因素个性化开药将有可能提高治疗的有效性和耐受性。在瑞士,任何医生都可以为五种可采取行动的药物开具经过验证的PGx检测:阿巴卡韦、卡马西平、硫嘌呤类药物[硫唑嘌呤]、氟嘧啶类药物[5-氟尿嘧啶、卡培他滨]和伊立替康。这种方法的前提是PGx数据要与经过培训的临床医生共享,并且开方辅助工具可以指导他们。

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