Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, Turkey.
Department of Virology, Faculty of Veterinary, Erciyes University, 38039 Kayseri, Turkey.
Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129801. doi: 10.1016/j.bbagen.2020.129801. Epub 2020 Nov 22.
Due to lack of approved drugs and vaccines, the medical world has resorted to older drugs, produced for viral infections and other diseases, as a remedy to combat COVID-19. The accumulating evidence from in vitro and in vivo studies for SARS-CoV and MERS-CoV have demonstrated that several polyphenols found in plants and zinc- polyphenol clusters have been in use as herbal medicines have antiviral activities against viruses with various mechanisms.
Curcumin, zinc and zinc-ionophores have been considered as nutraceuticals and nutrients showing great antiviral activities with their medicinal like activities.
In this work, we discussed the potential prophylactic and/or therapeutic effects of curcumin, zinc and zinc-ionophores in treatment of viral infections including COVID-19.
Curcuminoids and Zinc classified as nutraceuticals under GRAS (Generally Recognized As Safe) by FDA can provide complementary treatment for COVID 19 patients with their immunity-boosting and antiviral properties.
由于缺乏批准的药物和疫苗,医学界转而使用旧药物,这些药物是为病毒感染和其他疾病生产的,以治疗 COVID-19。针对 SARS-CoV 和 MERS-CoV 的体外和体内研究的累积证据表明,植物中发现的几种多酚和锌-多酚簇已被用作草药,对具有各种机制的病毒具有抗病毒活性。
姜黄素、锌和锌离子载体已被认为是具有药用活性的营养保健品和营养素,具有很强的抗病毒活性。
在这项工作中,我们讨论了姜黄素、锌和锌离子载体在治疗包括 COVID-19 在内的病毒感染中的潜在预防和/或治疗作用。
美国食品和药物管理局 (FDA) 将姜黄素类和锌归类为 GRAS(一般认为安全)的营养保健品,它们具有增强免疫力和抗病毒的特性,可为 COVID-19 患者提供补充治疗。