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食品和食品补充剂能否用于抗击 COVID-19 大流行?

Can food and food supplements be deployed in the fight against the COVID 19 pandemic?

机构信息

Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, Turkey.

Department of Virology, Faculty of Veterinary, Erciyes University, 38039 Kayseri, Turkey.

出版信息

Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129801. doi: 10.1016/j.bbagen.2020.129801. Epub 2020 Nov 22.

Abstract

BACKGROUND

Due to lack of approved drugs and vaccines, the medical world has resorted to older drugs, produced for viral infections and other diseases, as a remedy to combat COVID-19. The accumulating evidence from in vitro and in vivo studies for SARS-CoV and MERS-CoV have demonstrated that several polyphenols found in plants and zinc- polyphenol clusters have been in use as herbal medicines have antiviral activities against viruses with various mechanisms.

SCOPE OF REVIEW

Curcumin, zinc and zinc-ionophores have been considered as nutraceuticals and nutrients showing great antiviral activities with their medicinal like activities.

MAJOR CONCLUSIONS

In this work, we discussed the potential prophylactic and/or therapeutic effects of curcumin, zinc and zinc-ionophores in treatment of viral infections including COVID-19.

GENERAL SIGNIFICANCE

Curcuminoids and Zinc classified as nutraceuticals under GRAS (Generally Recognized As Safe) by FDA can provide complementary treatment for COVID 19 patients with their immunity-boosting and antiviral properties.

摘要

背景

由于缺乏批准的药物和疫苗,医学界转而使用旧药物,这些药物是为病毒感染和其他疾病生产的,以治疗 COVID-19。针对 SARS-CoV 和 MERS-CoV 的体外和体内研究的累积证据表明,植物中发现的几种多酚和锌-多酚簇已被用作草药,对具有各种机制的病毒具有抗病毒活性。

综述范围

姜黄素、锌和锌离子载体已被认为是具有药用活性的营养保健品和营养素,具有很强的抗病毒活性。

主要结论

在这项工作中,我们讨论了姜黄素、锌和锌离子载体在治疗包括 COVID-19 在内的病毒感染中的潜在预防和/或治疗作用。

一般意义

美国食品和药物管理局 (FDA) 将姜黄素类和锌归类为 GRAS(一般认为安全)的营养保健品,它们具有增强免疫力和抗病毒的特性,可为 COVID-19 患者提供补充治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b549/7680693/1a842bb38abb/gr1_lrg.jpg

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