Iversen Lars, Eriksen Patrick Rene Gerhard, Andreasen Simon, Clasen-Linde Erik, Homøe Preben, Wessel Irene, von Buchwald Christian, Heegaard Steffen
Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.
Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
Front Surg. 2020 Nov 6;7:581105. doi: 10.3389/fsurg.2020.581105. eCollection 2020.
Lymphoma of the sublingual gland is rare, representing 1% of all salivary gland lymphomas. In this case report, we present three new cases and compare them to previously published cases, with the aim of characterizing the clinical, morphological, histopathological, and genetic features of this type of malignancy. We provide a clinical description of three cases along with a characterization of the microscopic features, including morphology, and immunohistochemistry. In addition, we analysed possible cytogenetic rearrangements with the use of fluorescence hybridization (FISH). Case 1: A 61-year-old male presenting with a painless swelling of the floor of the mouth diagnosed as extranodal marginal zone lymphoma (EMZL) of the left sublingual gland. The patient is alive with no evidence of disease after his fourth treatment regimen following several relapses. Case 2: A 68-year-old female with a prior history of mantle cell lymphoma (MCL) presenting with a tender swelling of the left sublingual gland as well as the right submandibular gland. The lesions were diagnosed as relapsing MCL. The patient died of unrelated causes after 18 months of treatment. Case 3: A 75-year-old female presenting with a swelling of the floor of the mouth diagnosed as follicular lymphoma (FL) of the left sublingual gland. The patient received chemotherapy along with radiotherapy and was still alive 10 years after the diagnosis. The three cases of sublingual gland lymphomas presented in this case report resemble lymphomas of other major salivary glands. The clinician should be aware of this type of malignancy and that the clinical presentation may not differ from benign lesions or other more common malignancies in this location.
舌下腺淋巴瘤较为罕见，占所有涎腺淋巴瘤的1%。在本病例报告中，我们呈现3例新病例，并与既往发表的病例进行比较，旨在明确这类恶性肿瘤的临床、形态学、组织病理学及遗传学特征。我们提供了3例病例的临床描述以及显微镜下特征的描述，包括形态学和免疫组织化学。此外，我们使用荧光原位杂交（FISH）分析了可能的细胞遗传学重排。病例1：一名61岁男性，表现为口底无痛性肿胀，诊断为左舌下腺结外边缘区淋巴瘤（EMZL）。该患者在经历数次复发后接受了第四个治疗方案，目前存活且无疾病证据。病例2：一名68岁女性，既往有套细胞淋巴瘤（MCL）病史，表现为左舌下腺及右下颌下腺压痛性肿胀。病变诊断为复发性MCL。该患者在治疗18个月后死于无关原因。病例3：一名75岁女性，表现为口底肿胀，诊断为左舌下腺滤泡性淋巴瘤（FL）。该患者接受了化疗及放疗，诊断后10年仍存活。本病例报告中呈现的3例舌下腺淋巴瘤与其他主要涎腺的淋巴瘤相似。临床医生应了解这类恶性肿瘤，并且其临床表现可能与该部位的良性病变或其他更常见的恶性肿瘤并无差异。
