OTULIN将WNT信号传导与三阴性乳腺癌的耐药性联系起来。
OTULIN couples WNT signaling to resistance in triple-negative breast cancer.
作者信息
Wang Wei, Wu Zhao-Hui
机构信息
Department of Radiation Oncology, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Pathology and Laboratory Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Mol Cell Oncol. 2020 Oct 15;7(6):1825904. doi: 10.1080/23723556.2020.1825904. eCollection 2020.
Abstract
Oncogenic Wnt/β-catenin activation promotes cancer development and drug resistance to cancer treatments. We recently revealed an underlying mechanism linking linear ubiquitination with Wnt/β-catenin activation upon genotoxic treatments. We showed that ABL1 (ABL proto-oncogene 1)-dependent phosphorylation of OTULIN (OTU deubiquitinase with linear linkage specificity) upon DNA damage drives β-catenin activation which promotes drug resistance in triple-negative breast cancer.
摘要
致癌性Wnt/β-连环蛋白激活促进癌症发展和对癌症治疗的耐药性。我们最近揭示了一种在基因毒性治疗后将线性泛素化与Wnt/β-连环蛋白激活联系起来的潜在机制。我们发现，DNA损伤后，ABL1（ABL原癌基因1）依赖的OTULIN（具有线性连接特异性的OTU去泛素酶）磷酸化驱动β-连环蛋白激活，从而促进三阴性乳腺癌的耐药性。
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本文引用的文献
1
Activation of Wnt signaling promotes olaparib resistant ovarian cancer.
Mol Carcinog. 2019 Oct;58(10):1770-1782. doi: 10.1002/mc.23064. Epub 2019 Jun 10.
2
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization.
Cell Death Differ. 2018 Nov;25(10):1855-1869. doi: 10.1038/s41418-018-0138-z. Epub 2018 Jun 4.
3
Senescence-associated reprogramming promotes cancer stemness.
Nature. 2018 Jan 4;553(7686):96-100. doi: 10.1038/nature25167. Epub 2017 Dec 20.
4
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.
Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15.
5
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Mol Cell. 2014 May 8;54(3):349-61. doi: 10.1016/j.molcel.2014.03.016. Epub 2014 Apr 10.
6
Molecular basis and regulation of OTULIN-LUBAC interaction.
Mol Cell. 2014 May 8;54(3):335-48. doi: 10.1016/j.molcel.2014.03.018. Epub 2014 Apr 10.
7
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature. 2013 Jun 20;498(7454):318-24. doi: 10.1038/nature12296. Epub 2013 May 24.
8
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer.
Oncogene. 2010 Aug 26;29(34):4741-51. doi: 10.1038/onc.2010.215. Epub 2010 Jun 7.
9
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Dev Cell. 2009 Jul;17(1):9-26. doi: 10.1016/j.devcel.2009.06.016.
10
Functional interaction between DNA-PK and c-Abl in response to DNA damage.
Nature. 1997 Apr 17;386(6626):732-5. doi: 10.1038/386732a0.
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