Mikel Izquierdo, PhD, Department of Health Sciences, Public University of Navarra, Av. De Barañain s/n 31008 Pamplona (Navarra) Spain, Tel + 34 948 417876,
J Nutr Health Aging. 2020;24(10):1131-1139. doi: 10.1007/s12603-020-1480-7.
Aging-related traits, including gradual loss of skeletal muscle mass and chronic inflammation, are linked to altered body composition and impaired physical functionality, which are important contributing factors to the disabling process. We sought to explore the potential relationship between lower-body muscle strength decline and inflammatory mediators in older adults.
We performed a cross-sectional analysis in 38 older adults admitted to an acute care of the elderly unit (57.9% women, mean age=87.9±4.9 years; mean body mass index [BMI]=26.5±4.7 kg/m2). Clinical and functional outcomes including weight, height, BMI, dependence, physical and cognitive performance, and muscle strength measured by one-repetition maximum (1RM) for leg-extension, leg-press, chest-press and handgrip strength, were assessed. Blood serum content of 59 cytokines, chemokines and growth factors was assessed by protein arrays. Multivariate linear regression analyses were used to examine the relationship between cytokine concentrations and muscle strength parameters.
After controlling for confounding factors (age, sex, BMI, cumulative illness rating score and physical performance score), 1RM leg-press had a significant negative relationship with GRO (CXCL2) (β= -18.13, p=0.049), MIG (CXCL9) (β= -13.94, p=0.004), IGF-1 (β= -19.63, p=0.003), CK-BETA 8 (CCL23) (β= -28.31, p=0.018) and GCP-2 (CXCL6) (β= -25.78, p=0.004). Likewise, 1RM leg-extension had a significant negative relationship with IGFBP-1 (β= -11.49, p=0.023).
Thus, several serum cytokines/chemokines and growth factors are negatively associated with lower muscle strength in older patients. Further investigation is required to elucidate the mechanism of elevated inflammatory mediators leading to lower muscle strength.
与衰老相关的特征，包括骨骼肌质量的逐渐丧失和慢性炎症，与身体成分的改变和身体功能的受损有关，这些都是导致残疾过程的重要因素。我们试图探讨老年人下肢肌肉力量下降与炎症介质之间的潜在关系。
我们对 38 名入住老年急性护理病房的老年人进行了横断面分析（57.9%为女性，平均年龄=87.9±4.9 岁；平均体重指数 [BMI]=26.5±4.7kg/m2）。评估了临床和功能结局，包括体重、身高、BMI、依赖程度、身体和认知表现，以及通过 1 次重复最大量（1RM）测量的腿部伸展、腿部按压、胸部按压和握力强度。通过蛋白质阵列评估血液血清中 59 种细胞因子、趋化因子和生长因子的含量。采用多元线性回归分析评估细胞因子浓度与肌肉力量参数之间的关系。
在控制混杂因素（年龄、性别、BMI、累积疾病评分和身体表现评分）后，1RM 腿部按压与 GRO（CXCL2）（β= -18.13，p=0.049）、MIG（CXCL9）（β= -13.94，p=0.004）、IGF-1（β= -19.63，p=0.003）、CK-BETA 8（CCL23）（β= -28.31，p=0.018）和 GCP-2（CXCL6）（β= -25.78，p=0.004）呈显著负相关。同样，1RM 腿部伸展与 IGFBP-1（β= -11.49，p=0.023）呈显著负相关。
因此，几种血清细胞因子/趋化因子和生长因子与老年患者较低的肌肉力量呈负相关。需要进一步研究阐明导致肌肉力量降低的炎症介质升高的机制。
