静脉注射羟钴胺素治疗肝肾联合移植中血管扩张性综合征：一例报告。
Use of Intravenous Hydroxocobalamin for Vasoplegic Syndrome in Simultaneous Liver-Kidney Transplant: A Case Report.
机构信息
Department of Anesthesiology, Emory University, Atlanta, Georgia.
Department of Anesthesiology, Emory University, Atlanta, Georgia.
出版信息
Transplant Proc. 2021 May;53(4):1300-1302. doi: 10.1016/j.transproceed.2020.09.019. Epub 2020 Nov 24.
Vasoplegic syndrome can occur after reperfusion in liver transplantation. Generally, vasopressor infusions along with volume resuscitation are used to combat this process. There are case reports of the use of hydroxocobalamin to improve vasoplegia in liver transplant and cardiac surgery. In this case report, we describe a patient who received hydroxocobalamin for a simultaneous liver-kidney transplant. Use of this medication facilitated a prompt decrease of very high-dose vasopressor infusions and allowed completion of the kidney transplantation portion of this case. To our knowledge, use in combined liver-kidney transplant has not been described. In light of the dearth of medications to improve vasoplegia outside of vasopressor infusions, the use of hydroxocobalamin as a therapeutic intervention may gain importance.
血管扩张性综合征可发生于肝移植再灌注后。一般来说，会使用血管加压素输注和容量复苏来对抗这一过程。有羟钴胺素用于改善肝移植和心脏手术中血管扩张的病例报告。在本病例报告中，我们描述了一位接受羟钴胺素治疗的同时进行肝肾移植的患者。该药物的使用促使非常高剂量的血管加压素输注迅速减少，并完成了该病例的肾脏移植部分。据我们所知，这种药物在联合肝肾移植中尚未被描述。鉴于除血管加压素输注外，改善血管扩张的药物有限，因此羟钴胺素作为一种治疗干预手段可能会变得更加重要。
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