Akimoto Takayoshi, Hirose Satoshi, Mizoguchi Tomotaka, Yokota Yuki, Hara Makoto, Ishihara Masaki, Morita Akihiko, Nakajima Hideto
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan.
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan.
J Clin Neurosci. 2020 Dec;82(Pt B):249-251. doi: 10.1016/j.jocn.2020.10.054. Epub 2020 Nov 24.
Intramedullary spinal cord abscess (ISCA) is an extremely rare infection of the central nervous system. We report a 17-year old man with ISCA that suggested rupture confirmed by magnetic resonance imaging (MRI). The patient presented with meningeal signs, severe paraplegia, sensory impairment with a sensory level, and urinary retention. The cerebrospinal fluid (CSF) study showed pleocytosis with polymorphonuclear cells and a decreased glucose level suggesting bacterial meningitis. Computed tomography showed maxillary sinusitis and a lower respiratory tract infection. Spinal MRI showed an ISCA from Th5 to Th12. Part of the abscess seemed to have ruptured into the medullary cavity. Streptococcus intermedius was cultured from CSF, sputum, and the maxillary sinus abscess. It appeared that Streptococcus intermedius transferred from the respiratory tract to the spinal cord hematogenously, formed the ISCA, and the ISCA ruptured. The patient was treated with ampicillin, vancomycin, and meropenem. After 56 days of treatment, he could walk with a walker. In the present case, the MRI findings were helpful for early diagnosis and follow-up of the pathogenic condition. Although the present case suggested rupture of ISCA, he recovered with antibiotic therapy alone. This suggested earlier diagnosis with MRI and aggressive antibiotic therapy appear to be critical factors that determine the prognosis of patients with ISCA.
脊髓髓内脓肿(ISCA)是一种极为罕见的中枢神经系统感染。我们报告一例17岁患有ISCA的男性患者,磁共振成像(MRI)证实存在脓肿破裂迹象。患者出现脑膜刺激征、严重截瘫、伴有感觉平面的感觉障碍及尿潴留。脑脊液(CSF)检查显示多核细胞增多及葡萄糖水平降低,提示细菌性脑膜炎。计算机断层扫描显示上颌窦炎及下呼吸道感染。脊髓MRI显示胸5至胸12节段存在ISCA。部分脓肿似乎已破入髓腔。从脑脊液、痰液及上颌窦脓肿中培养出中间型链球菌。看来中间型链球菌经血液从呼吸道转移至脊髓,形成ISCA,随后ISCA破裂。患者接受氨苄西林、万古霉素和美罗培南治疗。治疗56天后,他能够借助助行器行走。在本病例中,MRI检查结果有助于早期诊断及对病情的随访。尽管本病例提示ISCA破裂,但仅通过抗生素治疗患者就康复了。这表明MRI早期诊断及积极的抗生素治疗似乎是决定ISCA患者预后的关键因素。