瘦素对性未成熟雄性鲐鱼促性腺激素分泌的体外作用。

In vitro action of leptin on gonadotropin secretion in pre-pubertal male chub mackerel.

机构信息

Fisheries Research Institute of Karatsu, Kyushu University, Saga 847-0132, Japan.

Laboratory of Marine Biology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

出版信息

Comp Biochem Physiol A Mol Integr Physiol. 2021 Mar;253:110856. doi: 10.1016/j.cbpa.2020.110856. Epub 2020 Nov 27.

DOI:10.1016/j.cbpa.2020.110856

PMID:33249145

Abstract

Leptin directly influences gonadotropin (GTH) secretion from female pituitary cells in vitro and is a key signal at the onset of puberty in female chub mackerel (Scomber japonicus). Here, we investigated whether leptin also influences GTH secretion in male chub mackerel. The addition of 1 nM homologous recombinant leptin to pre-pubertal male pituitary cells stimulated follicle-stimulating hormone secretion after 1 and 2 h of culture. Therefore, leptin signaling could also directly facilitate GTH secretion in male chub mackerel.

摘要

瘦素在体外直接影响雌性鲤鱼脑垂体细胞的促性腺激素（GTH）分泌，是雌性鲤鱼青春期开始的关键信号。在这里，我们研究了瘦素是否也会影响雄性鲤鱼的 GTH 分泌。将 1nM 同源重组瘦素添加到未成熟的雄性鲤鱼脑垂体细胞中，在培养 1 和 2 小时后刺激卵泡刺激素的分泌。因此，瘦素信号也可以直接促进雄性鲤鱼的 GTH 分泌。