Peptidorhamnomannans From and Species Display Microbicidal Activity Against Bacteria Commonly Present in Cystic Fibrosis Patients.

and species are filamentous fungi that cause a wide range of infections in humans. They are usually found in the lungs of cystic fibrosis (CF) patients and are the second most frequent fungal genus after species. Several studies have been recently performed in order to understand how fungi and bacteria interact in CF lungs, since both can be isolated simultaneously from patients. In this context, many bacterial molecules were shown to inhibit fungal growth, but little is known about how fungi could interfere in bacterial development in CF lungs. and species present peptidorhamnomannans (PRMs) in their cell wall that play crucial roles in fungal adhesion and interaction with host epithelial cells and the immune system. The present study aimed to analyze whether PRMs extracted from , , , and block bacterial growth and biofilm formation . PRM from and displayed the best bactericidal effect against methicillin resistant (MRSA), , and , but not , all of which are the most frequently found bacteria in CF lungs. In addition, biofilm formation was inhibited in all bacteria tested using PRMs at minimal inhibitory concentration (MIC). These results suggest that PRMs from the and surface seem to play an important role in colonization in CF patients, helping to clarify how these pathogens interact to each other in CF lungs.