Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Transpl Infect Dis. 2021 Jun;23(3):e13534. doi: 10.1111/tid.13534. Epub 2020 Dec 14.
Mucormycosis infrequently may present with isolated renal involvement. Among solid organ transplant recipients, renal allograft mucormycosis has been most often associated with medical tourism or transplantation outside of the western world. We report a case of an HIV/HCV co-infected woman who underwent simultaneous liver and kidney transplantation with a Public Health Service increased risk donor organ. 16 days after transplant, she developed massive hematuria and was found to have renal allograft Rhizopus spp. involvement, we surmise to have been from donor-derived infection. Therapy included nephrectomy, debridement, liposomal amphotericin B, and posaconazole with survival. We reviewed PubMed indexed, English-language cases of isolated renal mucormycosis in general, in HIV/AIDS, and from donor-derived renal allograft infections.
毛霉病很少表现为孤立性肾受累。在实体器官移植受者中,肾移植后毛霉病最常与医疗旅游或西方世界以外的移植有关。我们报告了一例 HIV/HCV 合并感染的妇女,她接受了同时进行的肝和肾移植,供体器官来自公共卫生服务增加风险的供体。移植后 16 天,她出现大量血尿,发现肾移植后 Rhizopus spp.受累,我们推测是来自供体来源的感染。治疗包括肾切除术、清创术、脂质体两性霉素 B 和泊沙康唑,患者存活。我们回顾了 PubMed 索引中关于一般情况下孤立性肾毛霉病、HIV/AIDS 和供体肾移植感染的英文病例。