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1996 年至 2015 年痴呆症死亡率:一项基于国家登记的队列研究。

Mortality in Dementia from 1996 to 2015: A National Registry-Based Cohort Study.

机构信息

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Alzheimers Dis. 2021;79(1):289-300. doi: 10.3233/JAD-200823.


DOI:10.3233/JAD-200823
PMID:33252077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7902977/
Abstract

BACKGROUND: It remains unclear whether the increased focus on improving healthcare and providing appropriate care for people with dementia has affected mortality. OBJECTIVE: To assess survival and to conduct a time trend analysis of annual mortality rate ratios (MRR) of dementia based on healthcare data from an entire national population. METHODS: We assessed survival and annual MRR in all residents of Denmark ≥65 years from 1996-2015 using longitudinal registry data on dementia status and demographics. For comparison, mortality and survival were calculated for acute ischemic heart disease (IHD) and cancer. RESULTS: The population comprised 1,999,366 people (17,541,315 person years). There were 165,716 people (529,629 person years) registered with dementia, 131,321 of whom died. From 1996-2015, the age-adjusted MRR for dementia declined (women: 2.76 to 2.05; men: 3.10 to 1.99) at a similar rate to elderly people without dementia. The sex-, age-, and calendar-year-adjusted MRR was 2.91 (95%CI: 2.90-2.93) for people with dementia. MRR declined significantly more for acute IHD and cancer. In people with dementia, the five-year survival for most age-groups was at a similar level or lower as that for acute IHD and cancer. CONCLUSION: Although mortality rates declined over the 20-year period, MRR stayed higher for people with dementia, while the MRR gap, compared with elderly people without dementia, remained unchanged. For the comparison, during the same period, the MRR gap narrowed between people with and without acute IHD and cancer. Consequently, initiatives for improving health and decreasing mortality in dementia are still highly relevant.

摘要

背景:目前尚不清楚对改善医疗保健和为痴呆症患者提供适当护理的日益重视是否会影响死亡率。

目的:评估生存情况,并根据来自整个国家人群的医疗保健数据,对痴呆症的年死亡率比(MRR)进行时间趋势分析。

方法:我们使用痴呆症状态和人口统计学的纵向登记数据,评估了 1996 年至 2015 年期间丹麦所有≥65 岁居民的生存情况和年 MRR。为了比较,还计算了急性缺血性心脏病(IHD)和癌症的死亡率和生存率。

结果:该人群由 1999366 人(17541315 人年)组成。有 165716 人(529629 人年)被登记为痴呆症患者,其中 131321 人死亡。从 1996 年至 2015 年,痴呆症的年龄调整 MRR 下降(女性:2.76 降至 2.05;男性:3.10 降至 1.99),与无痴呆症的老年人下降速度相似。性别、年龄和日历年调整后的 MRR 为 2.91(95%CI:2.90-2.93)。痴呆症患者的 MRR 下降幅度明显大于急性 IHD 和癌症患者。在痴呆症患者中,大多数年龄组的五年生存率与急性 IHD 和癌症相似或更低。

结论:尽管在 20 年期间死亡率有所下降,但痴呆症患者的 MRR 仍然较高,而与无痴呆症的老年人相比,MRR 差距保持不变。相比之下,在同一时期,患有和不患有急性 IHD 和癌症的患者之间的 MRR 差距缩小。因此,改善痴呆症患者的健康和降低死亡率的举措仍然非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/df0c7dd21d19/jad-79-jad200823-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/5d148238f8ae/jad-79-jad200823-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/06938c735cc8/jad-79-jad200823-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/938d62eec334/jad-79-jad200823-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/df0c7dd21d19/jad-79-jad200823-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/5d148238f8ae/jad-79-jad200823-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/06938c735cc8/jad-79-jad200823-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/938d62eec334/jad-79-jad200823-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/919b/7902977/df0c7dd21d19/jad-79-jad200823-g004.jpg

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[1]
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