Department of Radiology, Hershey Children's Hospital, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Department of Radiology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Radiol. 2020 Dec;50(13):2009-2027. doi: 10.1007/s00247-020-04769-z. Epub 2020 Nov 30.
Diagnosing musculoskeletal pathology requires understanding of the normal embryological development. Intrinsic errors of skeletal development are individually rare but are of paramount clinical importance because anomalies can greatly impact patients' lives. An accurate assessment of the fetal musculoskeletal system must be performed to provide optimal genetic counseling as well as to drive therapeutic management. This manuscript reviews the embryology of skeletal development and the appearance of the maturing musculoskeletal system on fetal MRI. In addition, it presents a comprehensive review of musculoskeletal fetal pathology along with postnatal imaging.
诊断肌肉骨骼系统病理学需要了解正常的胚胎发育。骨骼发育的内在错误虽然罕见,但具有至关重要的临床意义,因为异常会极大地影响患者的生活。必须对胎儿的肌肉骨骼系统进行准确评估,以便提供最佳的遗传咨询,并指导治疗管理。本文综述了骨骼发育的胚胎学以及胎儿 MRI 上成熟的肌肉骨骼系统的表现。此外,还全面回顾了肌肉骨骼系统的胎儿病理学以及产后影像学。