汉方药温清饮可减轻西妥昔单抗所致皮肤毒性的严重程度及表现：一例报告
Unseiin, a Kampo medicine, Reduces the Severity and Manifestations of Skin Toxicities Induced by Cetuximab: A Case Report.
作者信息
Taira Kenkichiro, Fujiwara Kazunori, Fukuhara Takahiro, Morisaki Tsuyoshi, Koyama Satoshi, Donishi Ryohei, Takeuchi Hiromi
机构信息
Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan.
出版信息
Yonago Acta Med. 2020 Nov 24;63(4):379-384. doi: 10.33160/yam.2020.11.020. eCollection 2020 Nov.
Cetuximab is an effective drug used to treat patients with recurrent or metastatic head and neck squamous cell carcinoma. Skin toxicities such as paronychia and skin exsiccation are common adverse events caused by cetuximab. Skin toxicities may cause significant physical and psychosocial discomfort. The goal of managing skin toxicities is to minimize the detrimental effects on quality of life and continue the treatment. In one patient, skin toxicities became severe, up to grade 2, during treatment. The pain induced by paronychia and skin exsiccation made daily life difficult. Ten days after starting Unseiin, symptoms and finger findings resolved significantly. The patient could resume daily activities. No adverse effects induced by Unseiin were observed during treatment. Unseiin was effective on paronychia and skin exsiccation in this case and may contribute to successful treatment of skin toxicities induced by cetuximab.
西妥昔单抗是一种用于治疗复发性或转移性头颈部鳞状细胞癌患者的有效药物。甲沟炎和皮肤干燥等皮肤毒性是西妥昔单抗引起的常见不良事件。皮肤毒性可能会导致严重的身体和心理不适。管理皮肤毒性的目标是尽量减少对生活质量的不利影响并继续治疗。在一名患者中，治疗期间皮肤毒性变得严重，达到2级。甲沟炎和皮肤干燥引起的疼痛使日常生活变得困难。开始使用温敏凝胶十天后，症状和手指状况明显改善。患者可以恢复日常活动。治疗期间未观察到温敏凝胶引起的不良反应。在该病例中，温敏凝胶对甲沟炎和皮肤干燥有效，可能有助于成功治疗西妥昔单抗引起的皮肤毒性。
Zotero 插件