Department of Pediatrics, University of British Columbia, BC Children's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
School of Population and Public Health, University of British Columbia, BC Children's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Reprod Toxicol. 2021 Jan;99:80-95. doi: 10.1016/j.reprotox.2020.11.013. Epub 2020 Nov 27.
The developmental impact of selective serotonin reuptake inhibitor (SSRI) and other antidepressant treatments during gestation and postpartum on anxiety and depression behaviors in offspring is unclear. This review focuses on how perinatal exposure to SSRI and other antidepressant may have long term consequences for these affective behaviors during early childhood and beyond. Outcomes vary and consideration is given to methodological factors related to how early SSRI exposure affects developments studied in rodent models such as: a) between pre- and early post-natal SSRI exposure, b) sex, c) experimental models of gestational maternal stress and d) impact of non-SSRI antidepressant medications. We will also review how multiple contextual factors (maternal caregiving and gene x environment interactions) may contribute to the effects of perinatal SSRI exposure and maternal mental illness on affective behaviors in children.
选择性 5-羟色胺再摄取抑制剂（SSRIs）和其他抗抑郁药物在妊娠和产后对后代焦虑和抑郁行为的发育影响尚不清楚。本综述重点关注围产期暴露于 SSRI 和其他抗抑郁药物如何对儿童早期及以后的这些情感行为产生长期影响。结果各不相同，并且考虑了与 SSRI 早期暴露如何影响啮齿动物模型中研究的发育相关的方法学因素，例如：a）产前和早期产后 SSRI 暴露之间，b）性别，c）妊娠期母体应激的实验模型，以及 d）非 SSRI 抗抑郁药物的影响。我们还将回顾多种环境因素（母婴照顾和基因 x 环境相互作用）如何影响围产期 SSRI 暴露和产妇精神疾病对儿童情感行为的影响。
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