cGAS-STING 信号通路在癌症免疫和免疫治疗中的作用。

cGAS-STING signaling in cancer immunity and immunotherapy.

机构信息

Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, No. 218, Ziqiang Road, Changchun, Jilin, 130041, People's Republic of China.

出版信息

Biomed Pharmacother. 2021 Jan;133:110972. doi: 10.1016/j.biopha.2020.110972. Epub 2020 Nov 27.

DOI:10.1016/j.biopha.2020.110972

PMID:33254021

Abstract

Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.

摘要

最近的研究表明，先天免疫环鸟苷酸-腺苷酸合酶-干扰素基因刺激物（cGAS-STING）途径可能在抗肿瘤免疫中发挥重要作用。此外，cGAS-STING 途径促进癌细胞衰老，诱导癌细胞凋亡，并增加细胞毒性 T 细胞和自然杀伤细胞介导的细胞毒性的保护作用。我们认为，将 cGAS-STING 信号通路与其他治疗方法相结合，为克服该综述应用中的障碍提供了新的视角。此外，我们强调了 cGAS-STING 信号通路的抗肿瘤机制，以及相关激动剂的单药治疗和联合治疗的最新进展。