非 ST 段抬高型心肌梗死患者中半乳糖凝集素-3 与 SYNTAX 评分 I 的关系。

The relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction.

机构信息

Department of Cardiology, Medline Hospital, Adana, Turkey.

Department of Cardiology, Okmeydanı Training and Research Hospital, İstanbul, Turkey.

出版信息

Turk Kardiyol Dern Ars. 2020 Nov;48(8):723-730. doi: 10.5543/tkda.2020.61987.

DOI:10.5543/tkda.2020.61987

PMID:33257615

Abstract

OBJECTIVE

The expression of galectin-3 has been found to be increased in human atherosclerotic lesions, suggesting a role in atherogenesis. However, there is a lack of data regarding an association between galectin-3 and the extent, severity, and complexity of coronary artery disease (CAD). The aim of this study was to investigate the relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction (NSTEMI).

METHODS

This study included a total of 95 consecutive patients who were diagnosed with NSTEMI and underwent coronary angiography. The baseline galectin-3 level of each patient was measured. The SYNTAX Score I of each patient was calculated using the online calculator (www.syntaxscore.com). The study population was divided into 2 groups: SYNTAX Score I ≤22 group (n=55) and SYNTAX Score I >22 group (n=40).

RESULTS

The galectin-3 level was significantly higher in the SYNTAX Score I >22 group than in the SYNTAX Score I ≤22 group (22.1±8.3 ng/mL vs. 13.5±7.7 ng/mL; p<0.001). Forward stepwise logistic regression analysis demonstrated that galectin-3 (odds ratio [OR]: 1.195, 95% confidence interval [CI]: 1.097-1.302; p<0.001), left ventricular ejection fraction (OR: 0.941, 95% CI: 0.888-0.997; p=0.040), and platelet count (OR: 1.013, 95% CI: 1.003-1.024; p=0.014) were independently associated with intermediate and high SYNTAX scores. ROC analysis provided a cut-off value of 14.0 ng/mL for galectin-3 to predict an intermediate or high SYNTAX Score I with 75.0% sensitivity and 51.0% specificity (p<0.001).

CONCLUSION

In patients with NSTEMI, galectin-3 was associated with the extent, severity, and complexity of CAD as assessed by the SYNTAX Score I.

摘要

目的

已有研究发现半乳糖凝集素-3在人类动脉粥样硬化病变中的表达增加，提示其在动脉粥样硬化形成中发挥作用。然而，关于半乳糖凝集素-3与冠状动脉疾病（CAD）的范围、严重程度和复杂性之间的关联，目前数据有限。本研究旨在探讨非 ST 段抬高型心肌梗死（NSTEMI）患者半乳糖凝集素-3与 SYNTAX 评分 I 之间的关系。

方法

本研究共纳入 95 例连续诊断为 NSTEMI 并接受冠状动脉造影的患者。测量每位患者的基线半乳糖凝集素-3水平。使用在线计算器（www.syntaxscore.com）计算每位患者的 SYNTAX 评分 I。研究人群分为 2 组：SYNTAX 评分 I ≤22 组（n=55）和 SYNTAX 评分 I >22 组（n=40）。

结果

SYNTAX 评分 I >22 组的半乳糖凝集素-3水平明显高于 SYNTAX 评分 I ≤22 组（22.1±8.3 ng/mL 比 13.5±7.7 ng/mL；p<0.001）。向前逐步逻辑回归分析表明，半乳糖凝集素-3（比值比[OR]：1.195，95%置信区间[CI]：1.097-1.302；p<0.001）、左心室射血分数（OR：0.941，95%CI：0.888-0.997；p=0.040）和血小板计数（OR：1.013，95%CI：1.003-1.024；p=0.014）与中高危 SYNTAX 评分独立相关。ROC 分析得出半乳糖凝集素-3 的截断值为 14.0 ng/mL，以预测中高危 SYNTAX 评分 I，其灵敏度为 75.0%，特异性为 51.0%（p<0.001）。