Gueguen-Duchesne M, Delamaire D, Durand F, Genetet B, Bourel M
Centre Régional de Transfusion Sanguine, Rennes, France.
Pathol Biol (Paris). 1987 Dec;35(10):1339-46.
Haemorheological parameters were studied in 138 alcoholic subjects at different stages of the liver disease, compared to non alcoholic liver diseases and controls. Results showed 1) a decrease in whole blood filterability in the three groups of alcoholic patients associated with a decrease in erythrocyte ATP level, 2) an increase in blood and plasma viscosities, 3) morphological alterations visualized by scanning electron microscopy. These disturbances are correlated to the abnormalities of red cell membrane lipids composition: increase in cholesterol/phospholipids ratio, increase in saturated fatty acids and decrease in polyunsaturated fatty acids (arachidonic and linoleic acids). The responsibility of alcohol itself, in the genesis of these disturbances has been demonstrated by acute alcohol drinking experiments in healthy subjects.
对138名处于肝病不同阶段的酒精性肝病患者的血液流变学参数进行了研究，并与非酒精性肝病患者和对照组进行了比较。结果显示：1）三组酒精性肝病患者的全血滤过率均下降，同时红细胞ATP水平降低；2）血液和血浆粘度增加；3）通过扫描电子显微镜观察到形态学改变。这些紊乱与红细胞膜脂质组成异常相关：胆固醇/磷脂比值增加、饱和脂肪酸增加以及多不饱和脂肪酸（花生四烯酸和亚油酸）减少。健康受试者的急性饮酒实验证明了酒精本身在这些紊乱发生过程中的作用。
