Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09123 Cagliari, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, 09123 Cagliari, Italy.
Int J Environ Res Public Health. 2020 Nov 28;17(23):8848. doi: 10.3390/ijerph17238848.
In people with multiple sclerosis (pwMS), fatigue, weakness and spasticity may reduce mobility and promote sedentary behavior. However, little is known about the existence of possible differences in the way MS modifies the propensity to perform physical activity (PA) in men and women. The present study aimed to partly close this gap by means of quantitative analysis carried out using wearable sensors. Forty-five pwMS (23 F, 22 M, mean age 50.3) and 41 unaffected age- and sex-matched individuals wore a tri-axial accelerometer 24 h/day for 7 consecutive days. Raw data were processed to calculate average number of daily steps, vector magnitude (VM) counts, and percentage of time spent in sedentary behavior and in PA of different intensities (i.e., light and moderate-to-vigorous, MVPA). Women with MS spent more time in sedentary behavior and exhibited a reduced amount of light intensity activity with respect to men, while MVPA was similar across sexes. However, in comparison with unaffected individuals, the overall PA patterns appear significantly modified mostly in women who, in presence of the disease, present increased sedentary behavior, reduced MVPA, number of daily steps and VM counts. The findings of the present study highlight the urgency of including sex as variable in all studies on PA in pwMS.
在多发性硬化症患者（pwMS）中，疲劳、虚弱和痉挛可能会降低活动能力并促进久坐行为。然而，对于 MS 如何改变男性和女性进行身体活动（PA）的倾向，目前知之甚少。本研究旨在通过使用可穿戴传感器进行定量分析来部分弥补这一差距。45 名 pwMS（23 名女性，22 名男性，平均年龄 50.3 岁）和 41 名年龄和性别匹配的未受影响的个体连续 7 天每天佩戴三轴加速度计 24 小时。原始数据经过处理，以计算每日平均步数、矢量幅度（VM）计数，以及久坐行为和不同强度（即轻强度和中高强度）PA 的时间百分比。与男性相比，患有 MS 的女性花更多的时间久坐，且轻强度活动量减少，而男女之间的中高强度活动量相似。然而，与未受影响的个体相比，总体 PA 模式发生了明显变化，主要是在女性中，她们在患病时表现出增加的久坐行为、减少的中高强度活动量、每日步数和 VM 计数。本研究的结果强调了在所有 pwMS 中进行 PA 研究时将性别作为变量纳入的紧迫性。
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