甾体糖苷类化合物来源于种子，及其在促进大鼠睾丸间质细胞睾酮生成中的作用。
Steroidal Glycosides from Seeds and Their Roles in Promoting Testosterone Production of Rat Leydig Cells.
机构信息
Key Laboratory of Coal Processing and Efficient Utilization, Ministry of Education, China University of Mining & Technology, Xuzhou 221116, Jiangsu, China.
Jiangsu Hanbon Science & Technology Co., Ltd., Huaian 223005, Jiangsu, China.
出版信息
Molecules. 2020 Nov 22;25(22):5464. doi: 10.3390/molecules25225464.
A systematic phytochemical study on the components in the seeds of was performed, leading to the isolation of 27 steroidal glycosides (SGs -). The structures of SGs were identified mainly by nuclear magnetic resonance and mass spectrometries as well as the necessary chemical evidence. In the SGs, - and - are new steroidal saponin analogues. An in vitro bioassay indicates that , , , , , -, , , and display promotional roles in testosterone production of rat Leydig cells with the EC values of 1.0 to 4.5 μM, respectively.
对 的种子成分进行了系统的植物化学研究，从中分离得到了 27 种甾体糖苷（SGs-）。SGs 的结构主要通过核磁共振和质谱以及必要的化学证据来确定。在 SGs 中，-和-是新的甾体皂苷类似物。体外生物测定表明，、、、、、-、、、和具有促进大鼠睾丸间质细胞睾酮产生的作用，EC 值分别为 1.0 至 4.5 μM。
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