NemChR-DB：寄生虫线虫化学感觉 G 蛋白偶联受体数据库。
NemChR-DB: a database of parasitic nematode chemosensory G-protein coupled receptors.
机构信息
Department of Biological Sciences, The George Washington University, Bell Hall 307, 2029 G Street NW, Washington, DC 20052, USA.
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC. USA.
出版信息
Int J Parasitol. 2021 Apr;51(5):333-337. doi: 10.1016/j.ijpara.2020.09.007. Epub 2020 Dec 1.
Nematode Chemosensory G-Protein Coupled Receptors have expanded within nematodes, where they play important roles in foraging and host-seeking behaviour. Nematode Chemosensory G-Protein Coupled Receptors are most highly expressed during free-living stages when chemosensory signalling is required for host detection and nematode activation in various parasitic nematodes, and therefore position Nematode Chemosensory G-Protein Coupled Receptors at the transition from infective to parasitic stages, making them important regulators to study in terms of host-seeking and host specificity. To facilitate the analysis of Nematode Chemosensory G-Protein Coupled Receptors, here we describe an integrative database of nematode chemoreceptors called NemChR-DB. This database enables users to study diverse parasitic nematode chemoreceptors, functionally explore sequence entries through structural and literature-based annotations, and perform cross-species comparisons.
线虫化学感觉 G 蛋白偶联受体在线虫中发生了扩张，它们在觅食和寻找宿主行为中发挥着重要作用。在自由生活阶段，当需要化学感觉信号来检测宿主并激活各种寄生线虫中的线虫时，线虫化学感觉 G 蛋白偶联受体表达水平最高，因此，线虫化学感觉 G 蛋白偶联受体处于从感染到寄生阶段的转变过程中，使其成为研究寻找宿主和宿主特异性的重要调节剂。为了便于分析线虫化学感觉 G 蛋白偶联受体，我们在这里描述了一个名为 NemChR-DB 的线虫化学感受器综合数据库。该数据库使用户能够研究不同的寄生线虫化学感受器，通过结构和基于文献的注释对序列条目进行功能探索，并进行跨物种比较。
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