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儿童期不良经历与成年期常见慢性病患病率关联的研究进展

[Progress in research of association of adverse childhood experiences with prevalence of common chronic diseases in adulthood].

作者信息

Qin F Z, Yuan M Q, Zhou Z, Fang Y

机构信息

Key Laboratory of Health Technology Assessment of Fujian Province University, School of Public Health, Xiamen University, Xiamen 361102, China.

School of Public Affairs, Xiamen University, Xiamen 361005, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Nov 10;41(11):1933-1937. doi: 10.3760/cma.j.cn112338-20191104-00783.

Abstract

The effects of adverse childhood experiences on adult health has aroused increasing concern in the world in recent years, but limited studies have been conducted in China. This study synthesized the measurement of adverse childhood experiences, the association between adverse childhood experiences and the prevalence common chronic diseases in adulthood and possible mechanisms. It was found that though measurement range of adverse childhood experiences might be different among studies, current used measurement scales basically met the requirement of disease prevention. Most categories of adverse childhood experiences were positively related to risk of common chronic diseases, and the relationship was influenced by social economic status, sex and age. However, people with exposure to famine in childhood had lower prevalence of hypertension compared with those without the exposure. The possible mechanisms might be that the occurrence of adverse childhood experiences might damage physiological functions or increase the adoption of poor healthy behaviors and lifestyles, and finally increased the risk of chronic diseases directly or indirectly. While premature death due to adverse childhood experiences might reverse the association because of nonrandom selection. It is necessary for us to select appropriate indexes of adverse childhood experiences and conduct more studies to prove the association between adverse childhood experiences and prevalence of common chronic diseases in adulthood and explore the related mechanism for the better prevention of chronic diseases in China.

摘要

近年来,童年不良经历对成人健康的影响在全球引起了越来越多的关注,但在中国开展的相关研究较少。本研究综合了童年不良经历的测量方法、童年不良经历与成年期常见慢性病患病率之间的关联以及可能的机制。研究发现,尽管不同研究中童年不良经历的测量范围可能有所不同,但目前使用的测量量表基本满足疾病预防的要求。大多数类型的童年不良经历与常见慢性病的风险呈正相关,且这种关系受社会经济地位、性别和年龄的影响。然而,童年时期经历过饥荒的人群与未经历过饥荒的人群相比,高血压患病率较低。可能的机制是,童年不良经历的发生可能损害生理功能,或增加不良健康行为和生活方式的养成,最终直接或间接增加慢性病风险。而童年不良经历导致的过早死亡可能会因非随机选择而使这种关联发生逆转。我们有必要选择合适的童年不良经历指标,开展更多研究以证实童年不良经历与成年期常见慢性病患病率之间的关联,并探索相关机制,以便更好地预防中国的慢性病。

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