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妊娠期糖尿病的眼部并发症——病例报告

OCULAR COMPLICATIONS OF DIABETES MELLITUS IN PREGNANCY - CASE REPORT.

作者信息

Schreiberová Z, Chrapek O, Šimičák J

出版信息

Cesk Slov Oftalmol. 2020 Summer;76(4):166-170. doi: 10.31348/2020/26.

Abstract

Pregnancy is associated with increased risk of progression of diabetic retinopathy (DR), the greatest risk of worsening occurs during the second trimester of pregnancy and persists as long as one year after the childbirth. The risk factors include duration of the diabetes, insufficient metabolic control, severity of DR at the time of conception and presence of coexisting vascular disease, such as arterial hypertension, and pregnancy itself. The recommendations for retinopathy screening in pregnancy vary significantly. A dilated fundus exam should be done in the beginning of pregnancy, the next follow-up throughout pregnancy depends on the severity of ocular findings. The cooperation of multi-disciplinary team consisting of ophthalmologist, obstetrition and endocrinologist is essential to provide the best health care. The authors present a case report of a pregnant woman with type 1 diabetes mellitus (DM), who had a progression of DR and diabetic macular edema (DME) in both eyes during pregnancy. She has had DM for 24 years and has been treated with insulin. The patient was examined at the 23rd week of the second pregnancy (first pregnancy was terminated because of missed miscarriage). The diagnosis of advanced proliferative DR and advanced DME in both eyes was made so we performed panretinal laser photocoagulation of the retina of both eyes. Despite that the ocular findings got worse and we found vitreous haemorrhage in the left eye. We performed pars plana vitrectomy (PPV) of the left eye at the 28th week of pregnancy, nevertheless the DME got worse in both eyes, so we recommended to terminate the pregnancy at the 31st week because of the risk of loss of vision. The visual acuity of the left eye improved, but suddenly there was vitreous haemorrhage in the right eye after the delivery. We indicated PPV of the right eye, the outcome of the surgery was satisfying. We still take care about this patient.

摘要

妊娠与糖尿病视网膜病变(DR)进展风险增加相关,病情恶化的最大风险出现在妊娠中期,且产后长达一年仍持续存在。风险因素包括糖尿病病程、代谢控制不佳、受孕时DR的严重程度以及并存血管疾病(如动脉高血压)的存在,还有妊娠本身。妊娠期间视网膜病变筛查的建议差异很大。妊娠开始时应进行散瞳眼底检查,整个孕期的后续随访取决于眼部检查结果的严重程度。由眼科医生、产科医生和内分泌科医生组成的多学科团队的合作对于提供最佳医疗保健至关重要。作者报告了一例1型糖尿病(DM)孕妇的病例,该孕妇在妊娠期间双眼DR和糖尿病性黄斑水肿(DME)均有进展。她患DM已24年,一直接受胰岛素治疗。该患者在第二次妊娠第23周时接受检查(第一次妊娠因稽留流产而终止)。诊断为双眼晚期增殖性DR和晚期DME,因此我们对双眼视网膜进行了全视网膜激光光凝。尽管如此,眼部检查结果仍恶化,且我们发现左眼玻璃体积血。我们在妊娠第28周时对左眼进行了玻璃体切割术(PPV),然而双眼DME仍恶化,因此由于存在视力丧失风险,我们建议在第31周终止妊娠。左眼视力有所改善,但产后右眼突然出现玻璃体积血。我们为右眼实施了PPV,手术结果令人满意。我们仍在关注这位患者。

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