Ji Yun-Xing, Li Jinxia, Li Chun-Min, Qu Shuanglin, Zhang Bo
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Org Lett. 2021 Jan 1;23(1):207-212. doi: 10.1021/acs.orglett.0c03916. Epub 2020 Dec 11.
A visible-light-promoted method for generating amidyl radicals from -fluorosulfonamides via a manganese-catalyzed N-F bond activation strategy is reported. This protocol employs a simple manganese complex, Mn(CO), as the precatalyst and a cheap silane, (MeO)SiH, as both the hydrogen-atom donor and the F-atom acceptor, enabling intramolecular/intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes. A wide range of valuable aliphatic sulfonamides can be readily prepared using these practical reactions.
报道了一种可见光促进的方法，通过锰催化的N-F键活化策略从氟磺酰胺生成酰胺基自由基。该方案采用简单的锰配合物Mn(CO)作为预催化剂，以及廉价的硅烷(MeO)SiH作为氢原子供体和氟原子受体，实现了烯烃的分子内/分子间氢胺化、烯烃的双组分碳胺化以及甚至烯烃的三组分碳胺化。使用这些实用反应可以很容易地制备各种有价值的脂肪族磺酰胺。
