锰催化的烯烃氢胺化和碳胺化反应中的N-F键活化
Manganese-Catalyzed N-F Bond Activation for Hydroamination and Carboamination of Alkenes.
作者信息
Ji Yun-Xing, Li Jinxia, Li Chun-Min, Qu Shuanglin, Zhang Bo
机构信息
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
出版信息
Org Lett. 2021 Jan 1;23(1):207-212. doi: 10.1021/acs.orglett.0c03916. Epub 2020 Dec 11.
A visible-light-promoted method for generating amidyl radicals from -fluorosulfonamides via a manganese-catalyzed N-F bond activation strategy is reported. This protocol employs a simple manganese complex, Mn(CO), as the precatalyst and a cheap silane, (MeO)SiH, as both the hydrogen-atom donor and the F-atom acceptor, enabling intramolecular/intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes. A wide range of valuable aliphatic sulfonamides can be readily prepared using these practical reactions.
报道了一种可见光促进的方法，通过锰催化的N-F键活化策略从氟磺酰胺生成酰胺基自由基。该方案采用简单的锰配合物Mn(CO)作为预催化剂，以及廉价的硅烷(MeO)SiH作为氢原子供体和氟原子受体，实现了烯烃的分子内/分子间氢胺化、烯烃的双组分碳胺化以及甚至烯烃的三组分碳胺化。使用这些实用反应可以很容易地制备各种有价值的脂肪族磺酰胺。
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