2nd Department of Gynecology, Medical University of Lublin, Lublin, Poland.
Department of Gynaecology, 1st Military Clinical Hospital with the Polyclinic in Lublin, Poland.
Neurourol Urodyn. 2021 Jan;40(1):529-537. doi: 10.1002/nau.24594. Epub 2020 Dec 11.
The aim of this study was to find the most clinically useful vesicovaginal fistula (VVF) classification system or single fistula-related factor, which would be helpful in determining the most proper management leading to successful treatment.
Between 2018 and 2020, 30 patients were diagnosed with VVF and underwent the Latzko procedure. Nineteen patients, after previously failed surgery, were injected with platelet-rich-plasma (PRP) before a final attempt to close VVF. Patients with primary VVF were included into the surgery only group and patients with secondary VVF were included into PRP and surgery group. Each patient was classified according to 13 different classification systems.
Statistical evaluation revealed some significant differences between the patients who required PRP injection and repeated surgery, compared with patients who were successfully treated at first surgery but only with Lawson, Waaldijk, Arrowsmith, and Tafesse classifications. Patients who succeded with the fistula closure after the first surgical procedure had significantly higher body mass index (BMI) when compared with patients who required PRP injection prior surgical procedure (30.9 vs. 25.7, respectively; p < .05).
None of the classification systems allows to precisely predict VVF surgery outcome. There are several factors such as previous surgery, lack of urethral involvement, lack of circumferential defect which might suggest that PRP injection would help to preserve watertightness of the closure. The most important finding is that overweight is the most positive predicting demographic feature of surgical success. Thus we may conclude that Martius flap technique should be taken into consideration in patients with low BMI.
本研究旨在找到最具临床实用价值的膀胱阴道瘘(VVF)分类系统或单一瘘管相关因素,这有助于确定最合适的管理方法,从而实现成功治疗。
2018 年至 2020 年间,30 例 VVF 患者接受了 Latzko 手术。19 例先前手术失败的患者在最后一次尝试闭合 VVF 之前接受了富含血小板的血浆(PRP)注射。原发性 VVF 患者被纳入手术组,继发性 VVF 患者被纳入 PRP 和手术组。每位患者根据 13 种不同的分类系统进行分类。
统计评估显示,与初次手术成功治疗但仅使用 Lawson、Waaldijk、Arrowsmith 和 Tafesse 分类的患者相比,需要 PRP 注射和重复手术的患者之间存在一些显著差异。首次手术成功闭合瘘管的患者的体重指数(BMI)明显高于需要术前 PRP 注射的患者(分别为 30.9 和 25.7;p<0.05)。
没有一种分类系统能够准确预测 VVF 手术结果。有几个因素,如先前的手术、无尿道受累、无环形缺陷,这可能表明 PRP 注射有助于保持闭合的密闭性。最重要的发现是超重是手术成功的最积极的预测人口统计学特征。因此,我们可以得出结论,对于 BMI 较低的患者,应考虑采用 Martius 皮瓣技术。