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加勒比国家风湿性心脏瓣膜病的现代外科治疗趋势。

Contemporary trends in surgical rheumatic valve disease in a Caribbean nation.

机构信息

CEDIMAT Cardiovascular Center, Santo Domingo, Dominican Republic.

CEDIMAT Cardiovascular Center, Santo Domingo, Dominican Republic.

出版信息

Int J Cardiol. 2021 Apr 1;328:215-217. doi: 10.1016/j.ijcard.2020.12.023. Epub 2020 Dec 10.

Abstract

BACKGROUND

Clinical practice suggests that rheumatic heart disease (RHD) represents a significant public health challenge in the Caribbean region where advanced disease appears early often leading to surgical intervention. We aimed to determine the burden of RHD and type of procedure among patients undergoing valve surgery in the Dominican Republic (DR).

METHODS

Demographic, clinical and procedural data of all subjects intervened between January 2014 and December 2018 were obtained including valve disorder, anatomic location and type of surgery. Correlation coefficients were used to assess yearly trends of RHD among the 7 cardiovascular surgical centers in the country.

RESULTS

Of 1626 valvular surgeries performed, 733 (45%) corresponded to RHD; 55% female patients, age 50 ± 11 (6-72) years; involving mitral 458 (63%); mitral + aortic 139 (19%); aortic 105 (14%); mitral + tricuspid 31 (4%); 95% prosthetic replacement and 5% mitral/tricuspid repairs. Mean proportion of RHD valve procedures per center for the study period was 53 ± 34%. Age-adjusted analysis showed an overall upwards trend in RHD valvular surgery (mean annual increment of 50 ± 40%, P = 0.01).

CONCLUSIONS

Despite inter-center variability, rates of surgical RHD in the DR increased during the last 5 years affecting a relatively young population. Mitral involvement was the predominant lesion and prosthetic replacement the leading procedure. These data may guide local and regional institutions and policy makers towards the implementation of cost-effective initiatives against RHD.

摘要

背景

临床实践表明,风湿性心脏病(RHD)在加勒比地区是一个重大的公共卫生挑战,该地区晚期疾病出现较早,往往需要手术干预。我们旨在确定多米尼加共和国(DR)接受瓣膜手术患者的 RHD 负担和手术类型。

方法

获取了 2014 年 1 月至 2018 年 12 月期间所有接受介入治疗的患者的人口统计学、临床和程序数据,包括瓣膜疾病、解剖位置和手术类型。使用相关系数评估了该国 7 个心血管外科中心的 RHD 逐年趋势。

结果

在 1626 例瓣膜手术中,733 例(45%)为 RHD;女性患者占 55%,年龄 50±11(6-72)岁;涉及二尖瓣 458 例(63%);二尖瓣+主动脉瓣 139 例(19%);主动脉瓣 105 例(14%);二尖瓣+三尖瓣 31 例(4%);95%为人工瓣膜置换术,5%为二尖瓣/三尖瓣修复术。研究期间,每个中心 RHD 瓣膜手术的平均比例为 53±34%。年龄调整分析显示,RHD 瓣膜手术总体呈上升趋势(平均每年递增 50±40%,P=0.01)。

结论

尽管各中心之间存在差异,但过去 5 年来,DR 接受手术治疗的 RHD 发病率有所上升,影响了相对年轻的人群。二尖瓣受累是主要病变,人工瓣膜置换术是主要手术。这些数据可能为当地和地区机构和决策者提供指导,以实施针对 RHD 的具有成本效益的举措。

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