前列腺癌与真性红细胞增多症之间的罕见关联。
A Rare Association Between Prostate Cancer and Polycythemia Vera.
作者信息
Elhaj Maab F, Yassin Mohamed A
机构信息
Internal Medicine, Hamad Medical Corporation, Doha, QAT.
Hematology and Oncology, Hamad General Hospital, Doha, QAT.
出版信息
Cureus. 2020 Nov 9;12(11):e11404. doi: 10.7759/cureus.11404.
The association of polycythemia vera (PV) and localized prostate cancer is uncommon. PV is one of the myeloproliferative neoplasms that is characterized by an increased red cell mass and uncontrolled formation of blood cells owing to an acquired mutation in Janus kinase-2. PV has numerous complications and could raise the hazard of other tumors. Here, we report an extremely rare association of localized prostate cancer in a 62-year-old male with PV. He was treated by CyberKnife surgery and completed four doses of goserelin and radiotherapy, his follow up Magnetic Resonance Imaging (MRI) four months after completion of treatment showed no recurrence, and the PV was treated with hydroxyurea 500 mg twice per day and repeated phlebotomies, when needed, to keep his hematocrit level under 45%.
真性红细胞增多症（PV）与局限性前列腺癌的关联并不常见。PV是一种骨髓增殖性肿瘤，其特征是红细胞量增加以及由于Janus激酶-2的获得性突变导致血细胞不受控制地生成。PV有许多并发症，并且可能增加其他肿瘤的风险。在此，我们报告一名62岁患有PV的男性患者出现极为罕见的局限性前列腺癌。他接受了射波刀手术治疗，并完成了四剂戈舍瑞林和放射治疗，治疗完成四个月后的随访磁共振成像（MRI）显示无复发，PV则通过每天两次服用500毫克羟基脲进行治疗，并在需要时反复进行放血，以将他的血细胞比容水平维持在45%以下。
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