钯催化烯丙醇与膦酸酯的 C-P 交叉偶联反应生成 2-膦酰基-1,3-丁二烯。

Palladium-catalyzed C-P cross-coupling of allenic alcohols with -phosphonates leading to 2-phosphinoyl-1,3-butadienes.

机构信息

Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.

出版信息

Chem Commun (Camb). 2021 Jan 14;57(3):339-342. doi: 10.1039/d0cc07022j.

DOI:10.1039/d0cc07022j

PMID:33315029

Abstract

The first facile, efficient, atom-economical and regioselective palladium-catalyzed direct C-P cross-coupling of unprotected allenic alcohols with H-phosphonates for the one-pot synthesis of structurally diverse multisubstituted 2-phosphinoyl-1,3-butadienes was developed. This strategy would enrich the allene chemistry and afford new scaffolds to construct complex molecular skeletons.

摘要

发展了一种简便、高效、原子经济性和区域选择性的钯催化的未保护烯丙醇与 H-膦酸酯的直接 C-P 交叉偶联反应，用于一锅法合成结构多样的多取代 2-膦酰基-1,3-丁二烯。该策略将丰富烯丙基化学，并为构建复杂分子骨架提供新的支架。