Faculty of Health Sciences, Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Eur J Clin Invest. 2021 May;51(5):e13472. doi: 10.1111/eci.13472. Epub 2020 Dec 24.
Increasing evidence suggests that L-homoarginine, an endogenous analogue of the amino acid L-arginine, may have beneficial effects on vascular homeostasis. We examined whether L-homoarginine is associated with 10-year risk of all-cause and cardiovascular mortality in a black South African population.
We included 669 black South African participants (mean age 59.5 years), 143 of whom died during the 10-year follow-up period. Mortality data were acquired via verbal autopsy. Plasma L-homoarginine (and other related markers) were analysed with liquid chromatography-tandem mass spectrometry.
Survivors had higher L-homoarginine levels compared with nonsurvivors (1.25 µM vs. 0.89 µM; P < .001). Multivariable Cox regression analyses revealed that higher plasma L-homoarginine predicted a reduction in 10-year cardiovascular (hazard ratio [HR] per SD increment, 0.61; 95% CI 0.50 to 0.75) and all-cause (hazard ratio [HR] per SD increment, 0.59; 95% CI 0.41 to 0.84) mortality risk.
Higher L-homoarginine levels are associated with reduced risk of 10-year cardiovascular and all-cause mortality. Regulation of L-homoarginine levels as a therapeutic target in the management of cardiovascular disease should be investigated.
越来越多的证据表明，L-同型精氨酸是一种内源性氨基酸 L-精氨酸类似物，可能对血管稳态有有益作用。我们研究了 L-同型精氨酸是否与南非黑人人群的全因和心血管死亡率 10 年风险相关。
我们纳入了 669 名南非黑人参与者（平均年龄 59.5 岁），其中 143 人在 10 年随访期间死亡。通过口头尸检获取死亡率数据。使用液相色谱-串联质谱法分析血浆 L-同型精氨酸（和其他相关标志物）。
幸存者的 L-同型精氨酸水平高于非幸存者（1.25µM 比 0.89µM；P<.001）。多变量 Cox 回归分析显示，较高的血浆 L-同型精氨酸预示着 10 年心血管（每 SD 增加的危险比，0.61；95%CI 0.50 至 0.75）和全因（每 SD 增加的危险比，0.59；95%CI 0.41 至 0.84）死亡率风险降低。
较高的 L-同型精氨酸水平与降低 10 年心血管和全因死亡率风险相关。应研究作为心血管疾病管理治疗靶点的 L-同型精氨酸水平的调节。
