腺嘌呤基琥珀酸：一种新型的 Nrf2 细胞保护剂诱导物，对杜氏肌营养不良症有疗效。
Adenylosuccinic acid: a novel inducer of the cytoprotectant Nrf2 with efficacy in Duchenne muscular dystrophy.
机构信息
Institute for Health and Sport, Victoria University, Melbourne, Australia.
Australian Institute for Musculoskeletal Science, Victoria University, St Albans, Australia.
出版信息
Curr Med Res Opin. 2021 Mar;37(3):465-467. doi: 10.1080/03007995.2020.1865699. Epub 2021 Jan 29.
Adenylosuccinic acid (ASA) modifies Duchenne muscular dystrophy (DMD) progression in dystrophic mice and human DMD patients. Despite an established role for ASA in augmenting metabolism and cellular energy homeostasis, our previous data suggests an undiscovered ulterior mode of action capable of modifying DMD disease course. Here, we identify ASA as a novel inducer of nuclear factor erythroid 2-related factor-2 (Nrf2), master regulator of the antioxidant and cytoprotective response to cell stress.
腺嘌呤基琥珀酸（ASA）可改善肌营养不良症（DMD）的进展。尽管 ASA 在增强代谢和细胞能量平衡方面具有既定作用，但我们之前的数据表明，它具有一种尚未发现的潜在作用机制，能够改变 DMD 的疾病进程。在这里，我们发现 ASA 是核因子红细胞 2 相关因子 2（Nrf2）的新型诱导剂，Nrf2 是细胞应激的抗氧化和细胞保护反应的主要调节剂。
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