奈诺沙星对[具体细菌名称未给出]、[具体细菌名称未给出]和[具体细菌名称未给出]抗菌活性的体外评价
[In vitro evaluation of the antibacterial activity of nemonoxacin against , and ].
作者信息
Jiang G L, Wang F, Xue Y, Jia J N, Huang H R
机构信息
The National Clinical Laboratory on Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Dec 12;43(12):1061-1065. doi: 10.3760/cma.j.cn112147-20200813-00896.
To test the in vitro antibacterial activity of nemonoxacin against clinically isolates of complex(MTBC), (MI) and (MA). Totally 128, 80 and 50 isolates of MTBC and were tested, respectively. The minimum inhibitory concentrations (MICs) of nemonoxacin and levofloxacin against the strains of the three most frequently isolated mycobacterium species were measured by double dilution method with micro-well plate. The MICs of 104(81.2%) strains of MTBC isolates against levofloxacin were ≤ 1 μg/ml. Whereas 112 (87.5%) strains of MTBC isolates had MICs against nemonoxacin than>1 μg/ml, furthermore, the MICs of 88(68.8%)strains of MTBC isolates against nemonoxacin were≥4 μg/ml. The median MIC of isolates against levofloxacin and nenofloxacin were 16 and 32 μg/ml, separately, while were 16 μg/ml and 8 μg/ml for , respectively. The ratios of nemonoxacin MIC/levofloxacin MIC of were between 0.125-1.000. Nemonoxacin presented weaker inhibitory activity than levofloxacin against , whereas it had better activity than levofloxacin against .
为测试奈诺沙星对结核分枝杆菌复合群（MTBC）、堪萨斯分枝杆菌（MI）和偶发分枝杆菌（MA）临床分离株的体外抗菌活性。分别对128株、80株和50株MTBC及MI和MA分离株进行了测试。采用微孔板双倍稀释法测定奈诺沙星和左氧氟沙星对三种最常分离的分枝杆菌菌株的最低抑菌浓度（MIC）。104株（81.2%）MTBC分离株对左氧氟沙星的MIC≤1μg/ml。而112株（87.5%）MTBC分离株对奈诺沙星的MIC>1μg/ml，此外，88株（68.8%）MTBC分离株对奈诺沙星的MIC≥4μg/ml。MI分离株对左氧氟沙星和奈诺沙星的MIC中位数分别为16μg/ml和32μg/ml，而MA分离株对左氧氟沙星和奈诺沙星的MIC中位数分别为16μg/ml和8μg/ml。MA的奈诺沙星MIC/左氧氟沙星MIC比值在0.125 - 1.000之间。奈诺沙星对MI的抑制活性比左氧氟沙星弱，而对MA的活性比左氧氟沙星好。
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