Shaheen Ghazala, Sajid Sabahat, Jahan Sarwat
Department of Animal Sciences, Reproductive Physiology lab, Quaid i Azam University, Islamabad, Pakistan.
J Pak Med Assoc. 2020 Nov;70(11):2048-2050. doi: 10.5455/JPMA.33057.
Preeclampsia (PE) is a pregnancy-related disorder involving multiple organ systems and characterised by an increase in hypertension and proteinuria after 20 weeks of gestation. The study aimed to determine the role of coagulation factors and ferritin in relation to PE susceptibility in Pakistani women. Blood samples of 100 normotensive and 100 preeclamptic women, including 73 with mild PE and 27 with severe PE were taken for the study to evaluate activated partial thromboplastin time (aPTT), prothrombin time (PT), international normalising ratio (INR), fibrinogen levels, platelet count (PLT) and ferritin levels. Prolonged aPTT, PT and INR were recorded in both PE groups with a decrease in platelets and fibrinogen levels, compared to the control groups. Ferritin levels were not significantly (p=0.23) different in any of the groups. In conclusion, coagulopathic disorder should be clinically suspected and the coagulating factors in PE patients should be examined for early detection, effective antenatal care and for the proper management of this disorder to decrease maternofoetal mortality, morbidity and perinatal mortality.
子痫前期（PE）是一种与妊娠相关的疾病，累及多个器官系统，其特征为妊娠20周后出现高血压和蛋白尿增加。该研究旨在确定凝血因子和铁蛋白在巴基斯坦女性子痫前期易感性方面的作用。采集了100名血压正常女性和100名子痫前期女性的血样进行研究，其中子痫前期女性包括73例轻度PE患者和27例重度PE患者，以评估活化部分凝血活酶时间（aPTT）、凝血酶原时间（PT）、国际标准化比值（INR）、纤维蛋白原水平、血小板计数（PLT）和铁蛋白水平。与对照组相比，两个PE组均记录到aPTT、PT和INR延长，血小板和纤维蛋白原水平降低。各亚组中铁蛋白水平无显著差异（p = 0.23）。总之，临床上应怀疑存在凝血病，应对PE患者的凝血因子进行检查，以便早期发现、进行有效的产前护理并妥善管理该疾病，从而降低母婴死亡率、发病率和围产期死亡率。
