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十三肋骨和长间隙食管闭锁:探索的胚胎学假说。

Thirteen ribs and long gap oesophageal atresia: The embryological hypothesis for exploration.

机构信息

Department of Pediatrics, Shanti Hospital, Bagalkot, Karnataka, India.

出版信息

Afr J Paediatr Surg. 2020 Jul-Dec;17(3 & 4):99-103. doi: 10.4103/ajps.AJPS_72_19.

DOI:10.4103/ajps.AJPS_72_19
PMID:33342843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8051636/
Abstract

CONTEXT

Since the gap between two atretic segments of oesophagus is a critical determinant of prognosis for oesophageal atresia/tracheoesophageal fistula (EA/TEF), the search for a surrogate non-invasive pre-operative marker of long gap atresia continues.

AIMS

The purpose of the study was to compare the presence of normal and supernumerary ribs with length of EA and survival rates.

SETTINGS AND DESIGN

A prospective observational study was conducted at a tertiary care referral neonatal intensive care unit in North Karnataka, India, from January 2016 to June 2019.

SUBJECTS AND METHODS

Amongst babies with EA/TEF, pre-operative radiograph helped determine the number of ribs, and babies were divided into two groups; Group I: babies with 12 ribs and Group II: babies with supernumerary ribs.

STATISTICAL ANALYSIS USED

Nominal variables were expressed as percentage and continuous variables as mean standard deviation. MedCalc software was used to compare proportions and means. A P < 0.05 was considered statistically significant.

RESULTS

Of the 61 cases, 51 were operated. Long gap EA was predominantly seen amongst babies in Group II (40% in Group II vs. 27% in Group I, P= 0.424). Survival rates by percentage were lower in babies in Group II (60% in Group II vs. 80% in Group I, P= 0.188). Both the above findings were proven statistically insignificant. The overall survival rate amongst the study population was 78.4% (39/51).

CONCLUSIONS

Supernumerary ribs were associated with a higher occurrence of long gap EA and lower survival rates, though statistically insignificant. Multicentre collaboration may provide significant input for strengthening or refuting the above hypothesis.

摘要

背景

食管闭锁/食管气管瘘(EA/TEF)患儿食管两吻合口间的距离是影响预后的关键因素,因此,人们一直致力于寻找一种非侵入性的术前预测长距离食管闭锁的替代指标。

目的

本研究旨在比较正常肋骨和额外肋骨的存在与 EA 长度和存活率的关系。

设置和设计

本前瞻性观察性研究于 2016 年 1 月至 2019 年 6 月在印度北 Karnataka 的一家三级医疗转诊新生儿重症监护病房进行。

研究对象和方法

在 EA/TEF 患儿中,术前 X 线片有助于确定肋骨数量,将患儿分为两组:第 I 组:有 12 根肋骨的患儿;第 II 组:有额外肋骨的患儿。

统计学分析

名义变量用百分比表示,连续变量用均数标准差表示。使用 MedCalc 软件比较比例和均值。P<0.05 被认为具有统计学意义。

结果

61 例患儿中,51 例接受了手术。第 II 组中长距离 EA 更为常见(第 II 组中 40%,第 I 组中 27%,P=0.424)。第 II 组患儿的存活率较低(第 II 组中 60%,第 I 组中 80%,P=0.188)。这两个发现均无统计学意义。研究人群的总体存活率为 78.4%(39/51)。

结论

额外肋骨与长距离 EA 的发生和存活率较低有关,尽管无统计学意义。多中心合作可能会为加强或反驳上述假设提供重要依据。

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本文引用的文献

1
13 ribs as a predictor of long gap esophageal atresia: myth or reality? Analysis of associated findings of esophageal atresia and abnormal rib count.13根肋骨作为长段食管闭锁预测指标:是谬论还是事实?食管闭锁相关发现及肋骨计数异常分析
J Pediatr Surg. 2017 Aug;52(8):1252-1254. doi: 10.1016/j.jpedsurg.2017.04.019. Epub 2017 May 2.
2
Long gap esophageal atresia: an Australian experience.长段食管闭锁:澳大利亚的经验
J Pediatr Surg. 2008 Apr;43(4):597-601. doi: 10.1016/j.jpedsurg.2007.12.001.
3
Association between long gap atresia and 13 ribs in neonates presenting with esophageal atresia and tracheoesophageal fistula.
食管闭锁及气管食管瘘新生儿中长段闭锁与13根肋骨之间的关联。
J Pediatr Surg. 1998 Aug;33(8):1328. doi: 10.1016/s0022-3468(98)90184-1.
4
13 pairs of ribs--a predictor of long gap atresia in tracheoesophageal fistula.13对肋骨——食管闭锁合并气管食管瘘长节段闭锁的一个预测指标。
J Pediatr Surg. 1997 Oct;32(10):1453-4. doi: 10.1016/s0022-3468(97)90560-1.
5
Vertebral anomalies associated with esophageal atresia and tracheoesophageal fistula with reference to the initial operative mortality.与食管闭锁及食管气管瘘相关的脊柱异常及其与初次手术死亡率的关系
J Pediatr Surg. 1973 Feb;8(1):9-13. doi: 10.1016/0022-3468(73)90287-x.