Universidade Federal de Juiz de Fora, Hospital Universitário, Divisão de Nefrologia, unidade de Transplante Renal, Juiz de Fora, MG, Brasil.
Núcleo Interdisciplinar de Estudos e Pesquisas em Nefrologia, Juiz de Fora, MG, Brasil.
J Bras Nefrol. 2021 Jul-Sep;43(3):318-329. doi: 10.1590/2175-8239-JBN-2019-0239.
Multidisciplinary clinics are the best approach towards Chronic Kidney Disease (CKD) patients in pre-dialysis phases. The few studies regarding kidney transplant recipients (KTR) compare multidisciplinary and non-multidisciplinary clinics.
In this study, we compared the quality of multidisciplinary CKD care between 101 KTR and 101 propensity score-matched non-transplant pre-dialysis patients (PDP). Prevalence of patients without specific treatment at any time and percent time without specific treatment for CKD complications were the main outcomes and patient and kidney function survival, glomerular filtration rate (GFR) decline, prevalence of CKD-related complications, and percent time within therapeutic goals were the exploratory ones.
Time within most goals was similar between the groups, except for diastolic blood pressure (83.4 vs. 77.3%, RR 0.92, CI 0.88-0.97, p = 0.002) and hypertriglyceridemia (67.7 vs. 58.2%, OR 0.85, CI 0.78-0.93, p < 0.001), better in non-transplant PDP, and for proteinuria (92.7 vs. 83.5%, RR 1.1, CI 1.05-1.16, p < 0.001), better in KTR. Patient survival and GFR decline were similar between the groups, although non-transplant PDP tended to progress earlier to dialysis (9.9% vs. 6.9%, HR 0.39, p = 0.07, CI 0.14-1.08).
The similar findings between non-transplant PDP and KTR suggests that good and comparable quality of multidisciplinary is a valid strategy for promoting optimal clinical management of CKD-related complications in KTR.
多学科诊所是透析前阶段慢性肾脏病(CKD)患者的最佳治疗方法。关于肾移植受者(KTR)的少数研究比较了多学科和非多学科诊所。
在这项研究中,我们比较了 101 名 KTR 和 101 名倾向评分匹配的非移植透析前患者(PDP)之间的多学科 CKD 护理质量。主要结局是任何时候没有特定治疗的患者比例和 CKD 并发症无特定治疗的时间百分比,探索性结局是患者和肾功能存活率、肾小球滤过率(GFR)下降、CKD 相关并发症的发生率和治疗目标内的时间百分比。
两组之间大多数目标的时间相似,除了舒张压(83.4%比 77.3%,RR 0.92,CI 0.88-0.97,p = 0.002)和高甘油三酯血症(67.7%比 58.2%,OR 0.85,CI 0.78-0.93,p < 0.001),非移植 PDP 更好,蛋白尿(92.7%比 83.5%,RR 1.1,CI 1.05-1.16,p < 0.001),KTR 更好。两组患者存活率和 GFR 下降相似,但非移植 PDP 倾向于更早进入透析(9.9%比 6.9%,HR 0.39,p = 0.07,CI 0.14-1.08)。
非移植 PDP 和 KTR 之间相似的发现表明,良好和可比的多学科质量是促进 KTR CKD 相关并发症最佳临床管理的有效策略。