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A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
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RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.
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Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11.
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本文引用的文献

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Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
Cell Mol Gastroenterol Hepatol. 2021;11(4):1071-1094. doi: 10.1016/j.jcmgh.2020.11.005. Epub 2020 Nov 11.
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
Nat Med. 2015 May;21(5):449-56. doi: 10.1038/nm.3850. Epub 2015 Apr 20.
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Comprehensive molecular characterization of gastric adenocarcinoma.
Nature. 2014 Sep 11;513(7517):202-9. doi: 10.1038/nature13480. Epub 2014 Jul 23.
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HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target.
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